ArticleMethods in molecular biology (Clifton, N.J.)2026
Generating Human Blastoids Following Transient Naïve Resetting of Primed Pluripotent Stem Cells.
Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
Human pluripotent stem cells (hPSCs) exist in at least two distinct states of pluripotency: naïve and primed. While naïve hPSCs possess the unique ability to generate blastocyst-like structures, they are often genetically and epigenetically unstable, which compromises the quality and developmental potential of naïve hPSC-derived blastoids. This protocol presents an optimized human blastoid protocol through a transient resetting method that converts primed hPSCs into a naïve-like state, addressing the stability issues associated with long-term naïve hPSC maintenance. The approach is compatible with both feeder-free and feeder-based culture systems and demonstrates high efficiency in generating human blastoids directly from primed hPSCs. This advancement provides a more robust and reliable strategy for blastoid formation, circumventing the limitations of suboptimal naïve hPSC cultures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.