ArticleDiscover oncology2025
Clinical characteristics, treatment patterns, and survival outcomes of 1031 patients with peripheral T cell lymphoma in china: a multicenter, real-world study.
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Real-world treatment patterns and outcomes of brentuximab vedotin-based therapy in CD30-positive lymphomas in China: the prospective BRAVE study.Blood cancer journal · 2026Article
- Synergistic adverse prognostic impact of CD30 and Epstein-Barr virus in peripheral T-cell lymphoma: CD30 identifies a high-risk subgroup in Epstein-Barr virus-encoded RNA -positive patients.Annals of hematology · 2026Article
- [Chinese expert consensus on the diagnosis and management of nodal peripheral T-cell lymphoma (2025)].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2025Article
- Epstein-barr virus-encoded small RNA incorporated prognostic model enables precision risk stratification and guides treatment decisions in peripheral t-cell lymphoma: a multicenter retrospective cohort.Annals of hematology · 2025Article
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37 authors.
Funding
Abstract
backgroundThe data about the clinical features and outcomes of Chinese patients with peripheral T-cell lymphomas (PTCLs) are limited.
methodThis retrospective study included 1031 patients of PTCL from January 2014 to March 2022 at 21 centers in China. The clinical features, treatment patterns, and survival outcomes of the Chinese PTCL population were reported.
resultsAmong the 1031 patients, 937 patients had mature T or NK cell lymphoma (91.2%). The most common subtype was extranodal NK/T-cell lymphoma, nasal type (35.5%). The median age was 52 years, most patients had stage III-IV, and fewer patients had infiltrated bone marrow. Approximately 50% of PTCL patients received anthracycline-based chemotherapies. After a median of 25.9 months of follow-up, the median overall survival (OS) and first-line progression-free survival (1 L PFS) were 83.8 and 30.5 months, respectively. Besides, the OS and 1 L PFS were significantly different among the majority of common subtypes (P < 0.05). Multivariate analysis confirmed that age, lactate dehydrogenase level, beta-2 microglobulin level, Eastern Cooperative Oncology Group Performance Status, and histologic subtypes were independent prognostic factors for survival. The CD30 was expressed across all subtypes (P < 0.05). Patients with the AITL subtype who were CD30-negative had significantly better survival outcomes than those with CD30-positive (median OS of 32.8 vs. 15.0 months, P = 0.02; median 1 L PFS of 11.0 vs. 5.2 months, P < 0.01).
conclusionsWe revealed the clinical characteristics and outcomes of PTCL patients in the real world in China, which may provide novel data on prognostic factors and primary treatment of PTCLs, applicable to routine clinical practice.
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