Evidence map›Paper›PMID 40601110›Full record

ArticleCancer causes & control : CCC2025

Sitting time and risk of cancer incidence and cancer mortality in postmenopausal women: the Women's Health Accelerometry Collaboration.

Eric T Hyde, Kelly R Evenson, Annie Green Howard, Humberto Parada, Chongzhi Di, Michael J LaMonte, John Bellettiere, Carmen C Cuthbertson, I-Min Lee, Andrea Z LaCroix

Abstract read
In one paragraph

Article in Cancer causes & control : CCC, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Eric T HydeHerbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA. ehyde@health.ucsd.edu.ORCID http://orcid.org/0000-0002-5896-0894
Kelly R EvensonDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0002-3720-5830
Annie Green HowardDepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0003-0837-8166
Humberto ParadaDivision of Epidemiology and Biostatistics, School of Public Health, San Diego State University, San Diego, CA, USA.ORCID http://orcid.org/0000-0001-6562-8577
Chongzhi DiDivision of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-1371-581X
Michael J LaMonteDepartment of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo-SUNY, Buffalo, NY, USA.ORCID http://orcid.org/0000-0002-6669-5242
John BellettiereHerbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.ORCID http://orcid.org/0000-0002-7167-3048
Carmen C CuthbertsonDepartment of Health Education and Promotion, East Carolina University, Greenville, NC, USA.ORCID http://orcid.org/0000-0001-5145-9098
I-Min LeeDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1083-6907
Andrea Z LaCroixHerbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.ORCID http://orcid.org/0000-0002-9532-976X

Funding

San Diego Resource Center for advancing Alzheimer's Research in Minority Seniors (ARMS)P30AG059299 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Tala Al-Rousan · 2018 to 2026
$7.4M
WOMEN'S HEALTH INITIATIVE (WHI) REGIONAL CENTER (RC): TASK AREA A AND A275N92021D00002 · NHLBI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI WACTAWSKI-WENDE, JEAN · 2021 to 2025
$6.9M
TALENT Shared Resources CoreU54CA285115 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI James D Murphy · 2023 to 2026
$6.6M
Physical Activity to Improve CV Health in Older Women: A Pragmatic TrialR33HL151885 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI KOOPERBERG, CHARLES L, LACROIX, ANDREA Z. · 2021 to 2023
$6.4M
Objective Physical Activity and Cardiovascular Health in Older Women: OPACH2R01HL153462 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LACROIX, ANDREA Z., LAMONTE, MICHAEL J · 2022 to 2025
$6.2M
Research Education CoreU54CA285117 · NCI · SAN DIEGO STATE UNIVERSITY · PI Richard Matthew Cripps, MARIA ELENA MARTINEZ · 2023 to 2026
$6.2M
Statistical methods for analyzing objectively measured physical activity dataR01HL130483 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Chongzhi Di · 2016 to 2026
$4.4M
WHISH-2-Prevent Heart Failure StudyR01HL130591 · NHLBI · MEMORIAL HOSPITAL OF RHODE ISLAND · PI EATON, CHARLES B · 2016 to 2020
$3.1M
Racial/Ethnic Disparities in Heart Failure: A Cross Cohort CollaborationR01HL150170 · NHLBI · KENT COUNTY MEMORIAL HOSPITAL · PI ALLEN, NORRINA BAI, EATON, CHARLES B · 2021 to 2024
$2.8M
Physical Activity to Improve CV Health in Older Women: A Pragmatic TrialR61HL151885 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI KOOPERBERG, CHARLES L, LACROIX, ANDREA Z. · 2020 to 2020
$2.5M
Red Blood Cell Polyunsaturated Fatty Acids and Breast Cancer Mortality in the Women's Healthy Eating and Living (WHEL) StudyK01CA234317 · NCI · SAN DIEGO STATE UNIVERSITY · PI PARADA, HUMBERTO · 2019 to 2023
$928k
NCI NIH HHS K01 CA234317NCI NIH HHS U54 CA285115NCI NIH HHS U54 CA285117NHLBI NIH HHS 75N92021D00002NHLBI NIH HHS 75N92021D00002, HL153462, HL151885, HL150170, and HL130591NHLBI NIH HHS R01 HL130483NHLBI NIH HHS R01 HL130591NHLBI NIH HHS R01 HL150170NHLBI NIH HHS R01 HL153462NHLBI NIH HHS R33 HL151885NHLBI NIH HHS R61 HL151885NHLBI NIH HHS T32HL07989NIA NIH HHS P30 AG059299SDSU/UCSD Cancer Center Comprehensive Partnership U54 CA285117 & U54 CA285115Tobacco-Related Disease Research Program 31KT1501
6 · The paper itself

Abstract

purposeFew studies have explored whether accelerometer-measured sedentary behavior increases cancer risk. We examined the associations of accelerometer-measured daily sitting time and mean sitting bout duration classified by the Convolutional Neural Network Hip Accelerometer Posture (CHAP) machine-learned algorithm with incidence of any cancer, incidence of 13 physical activity-related cancers, and cancer mortality among postmenopausal women.

methodsWe used data from 22,097 women (mean age = 73.3 years, standard deviation [SD] = 6.7) in the Women's Health Accelerometry Collaboration, a consortium of two US-based cohort studies of postmenopausal women: the Women's Health Study and the Women's Health Initiative Objective Physical Activity and Cardiovascular Health Study. Women who completed hip-worn triaxial accelerometry for ≥ 4 of 7 consecutive days were included. Associations between sedentary behaviors and physician-adjudicated invasive cancer incidence and mortality were tested using Cox regression.

resultsWomen were followed on average 8.0 years to identify cancer cases (n = 1,861) and deaths (n = 601). Overall, mean sitting time was 567 (SD = 113) min/day and mean sitting bout duration was 12.8 (SD = 4) min/bout. In covariate-adjusted models, one-SD increment higher in sitting time was associated with a 6% increased risk of incident cancer (hazard ratio [HR] = 1.06, 95% CI: 1.01-1.11); associations were similar for bout duration (HR = 1.05, 95% CI: 1.00-1.10). Estimates were similar for the 13 physical activity-related cancers (sitting time: HR = 1.10, 95% CI: 1.04-1.17; bout duration: HR = 1.08, 95% CI: 1.02-1.14) and for cancer mortality (sitting time: 1.06, 95% CI: 0.98-1.16; bout duration: HR = 1.05, 95% CI: 0.97-1.13).

conclusionAmong postmenopausal women, sedentary behavior was associated with increased cancer risk, particularly for physical activity-related cancers and cancer mortality.

Indexed as

NeoplasmsPostmenopauseSedentary BehaviorSitting PositionAccelerometryAgedCohort StudiesExerciseFemaleHumansIncidenceMiddle AgedRisk FactorsUnited StatesWomen's HealthAccelerometerBoutsMachine learningSittingWomen’s health

Identifiers

PMID40601110
PMCPMC12578691

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.