Evidence map›Paper›PMID 40601067›Full record

ArticleNeuroradiology2025

Histology of PFO-associated stroke thrombus compared to iliofemoral deep vein thrombus: an explorative study.

M H M Immens, M Stam, D W J Dippel, G J Lycklama À Nijeholt, H B van der Worp, S Jenniskens, M J van Rijn, F E de Leeuw, T J F Ten Cate, H M M van Beusekom and 1 more

Abstract readMulticenter StudyComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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5 · Who and what money

Authors and funding

11 authors.

M H M ImmensDonders Institute for Brain, Cognition and Behaviour, Department of Neurology, Radboud University Medical Center, Nijmegen, Netherlands.
M StamDepartment of Cardiology, Erasmus Medical Center, Rotterdam, the Netherlands.
D W J DippelDepartment of Neurology, Erasmus Medical Center, Rotterdam, the Netherlands.
G J Lycklama À NijeholtDepartment of Radiology, Haaglanden Medical Center, The Hague, the Netherlands.
H B van der WorpDepartment of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht, the Netherlands.
S JenniskensDepartment of Radiology, Radboud University Medical Center, Nijmegen, the Netherlands.
M J van RijnDepartment of Vascular Surgery, Erasmus Medical Center, Rotterdam, the Netherlands.
F E de LeeuwDonders Institute for Brain, Cognition and Behaviour, Department of Neurology, Radboud University Medical Center, Nijmegen, Netherlands.
T J F Ten CateDepartment of Cardiology, Radboud University Medical Center, Nijmegen, the Netherlands.
H M M van BeusekomDepartment of Cardiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Anil M TuladharDonders Institute for Brain, Cognition and Behaviour, Department of Neurology, Radboud University Medical Center, Nijmegen, Netherlands. anil.tuladhar@radboudumc.nl.

Funding

Abbott Vascular Abbott VascularToegepast Wetenschappelijk Instituut voor Neuromodulatie Toegepast Wetenschappelijk Instituut voor Neuromodulatie
6 · The paper itself

Abstract

purposeA patent foramen ovale (PFO) is as a cause of thrombo-embolic stroke. It is thought that the thrombus originates from the venous circulation, although this has never been proven. The histological composition of the thrombus might help to identify its origin. The aim of this exploratory pilot study is to compare the histological composition of thrombi of patients with PFO-associated stroke with venous thrombi from patients with iliofemoral deep venous thrombosis (DVT).

methodsWe retrieved thrombi from the MR CLEAN Registry, a Dutch nationwide, multicenter, prospective registry of patients who underwent endovascular treatment for ischemic stroke. Furthermore DVT thrombi were obtained as fully anonymous waste material and analyzed retrospectively.

resultsThrombi were available for three patients treated for PFO-associated stroke and four patients treated for DVT. The thrombi of patients with PFO-associated stroke contained less red blood cells (RBC) and more fibrin and platelets (Fib + Plt) than those with DVT (30.2% vs. 91.3% RBC and 67.4% vs. 8.5% Fib + Plt). The PFO-associated stroke thrombi were most comparable to thrombi from the same cohort classified as cardioembolic (RBC 25.8% and 67.1% Fib + Plt). As this is a descriptive histological analysis, no definitive comparisons between different thrombi can be made.

conclusionWe observed that the composition of the three thrombi from patients with PFO-associated stroke differs from that of the four DVT thrombi in our cohort. Prospective studies are needed to determine whether thrombi in PFO-associated stroke are all similar in composition and share a similar pathophysiology with venous thrombi.

Indexed as

Femoral VeinForamen Ovale, PatentIliac VeinStrokeVenous ThrombosisAgedFemaleHumansMaleMiddle AgedNetherlandsPilot ProjectsRegistriesRetrospective StudiesHistologyPatent foramen ovaleStroke

Identifiers

PMID40601067
PMCPMC12546273

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