Evidence map›Paper›PMID 40601040›Full record

ArticleEuropean child & adolescent psychiatry2025

White matter microstructure of the cingulum bundle and the uncinate fasciculus in primary and secondary callous-unemotional traits.

Luisa Schalk, Arjun Sethi, Melanie C Saam, Itziar Flamarique, Jilly Naaijen, Andrea Dietrich, Pieter J Hoekstra, Tobias Banaschewski, Pascal-M Aggensteiner, Nathalie Holz and 17 more

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Article in European child & adolescent psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

27 authors.

Luisa Schalk *Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College, London, UK. luisaschalk@gmx.de.ORCID https://orcid.org/0009-0006-9387-3741
Arjun Sethi *Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College, London, UK.ORCID https://orcid.org/0000-0001-5352-4164
Melanie C SaamDepartment of Child and Adolescent Psychiatry/Psychotherapy, University Hospital, University of Ulm, Ulm, Germany.ORCID https://orcid.org/0000-0002-5311-8673
Itziar FlamariqueDepartment of Child and Adolescent Psychiatry and Psychology, Clinic Institute of Neurosciences, Hospital Clínic de Barcelona, 2017SGR881, IDIBAPS, CIBERSAM, Barcelona, Spain.
Jilly NaaijenDepartment of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, The Netherlands.
Andrea DietrichDepartment of Child and Adolescent Psychiatry, University of Groningen, University Medical Center, Groningen, The Netherlands.
Pieter J HoekstraDepartment of Child and Adolescent Psychiatry, University of Groningen, University Medical Center, Groningen, The Netherlands.
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.
Pascal-M AggensteinerDepartment of Child and Adolescent Psychiatry and Psychotherapy, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.
Nathalie HolzDepartment of Child and Adolescent Psychiatry and Psychotherapy, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.
Sarah BaumeisterDepartment of Child and Adolescent Psychiatry and Psychotherapy, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.
Roger BorràsDepartment of Child and Adolescent Psychiatry and Psychology, Clinic Institute of Neurosciences, Hospital Clinic de Barcelona, IDIBAPS, Barcelona, Spain.
Mireia Rosa-JusticiaDepartment of Child and Adolescent Psychiatry and Psychology, Clinic Institute of Neurosciences, Hospital Clinic de Barcelona, IDIBAPS, Barcelona, Spain.
Paramala SantoshDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College, London, UK.
Ilyas Sagar-OuriaghliDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College, London, UK.
Celso ArangoDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, CIBERSAM, ISCIII, School of Medicine, Hospital General Universitario Gregorio Marañón, Universidad Complutense, IiSGM, Madrid, Spain.
María José PenzolDepartment of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, CIBERSAM, ISCIII, School of Medicine, Hospital General Universitario Gregorio Marañón, Universidad Complutense, IiSGM, Madrid, Spain.
Daniel BrandeisDepartment of Child and Adolescent Psychiatry and Psychotherapy, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany.
Susanne WalitzaDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland.
Julia E WerhahnDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland.
Barbara FrankeDepartment of Human Genetics, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, The Netherlands.
Jeffrey C GlennonDepartment of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, The Netherlands.
Marcel P ZwiersDepartment of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, The Netherlands.
Ulrike M E SchulzeDepartment of Child and Adolescent Psychiatry/Psychotherapy, University Hospital, University of Ulm, Ulm, Germany.
Josefina Castro-FornielesDepartment of Child and Adolescent Psychiatry and Psychology, Department of Medicine, Institute of Neuroscience, 2021SGR01319, Institut Clinic de Neurociències, Hospital Clínic de Barcelona, IDIBAPS, CIBERSAM, University of Barcelona, Barcelona, Spain.
Jan K Buitelaar *Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, Nijmegen, The Netherlands.
Michael C Craig *Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College, London, UK.

Funding

European Union's Seventh Framework Programme for research, technological development, and demonstration 602805
6 · The paper itself

Abstract

Callous-unemotional (CU) traits appear to be linked to differences in neural networks, including the uncinate fasciculus (UF) and cingulum bundle (CB). It has recently been suggested that CU traits are comprised of primary and secondary subtypes based on the relative co-occurrence of internalising symptoms. Here, we explored the white matter microstructure of these subtypes. White matter microstructure of the UF and CB was analysed in youths (aged 8–18; n = 121; females = 31) recruited through Europe-based multisite studies. Our sample comprised a control (n = 53) and a case group with disruptive behaviour disorders (DBDs) (n = 68) with low and high levels of CU traits. The case group was further split into primary (n = 49) and secondary (n = 14) subgroups. Compared to the control group, the case group showed decreased mean diffusivity in the right ventral CB (p =.023, uncorrected). Within our case group, higher scores on the ‘unemotional’ subscale of the Inventory of Callous Unemotional Traits were associated with decreased axial diffusivity (p =.02, uncorrected) and mean diffusivity (p =.013, uncorrected) in the dorsal CB in youths with primary CU traits, but the opposite in those with secondary CU traits. Post hoc analyses found that the left hemisphere drove these effects. The relationship between CU traits and dorsal CB microstructure appears dependent on the presence of internalising symptoms and CU traits subcomponents. A fractionation may lead to a better understanding of the aetiology of DBDs and more focused treatment options.

Indexed as

Attention Deficit and Disruptive Behavior DisordersConduct DisorderEmotionsGyrus CinguliUncinate FasciculusWhite MatterAdolescentChildDiffusion Tensor ImagingFemaleHumansMaleCallous-unemotional traitsCingulum bundleDisruptive behaviour disordersInternalisingUncinate fasciculus

Identifiers

PMID40601040
PMCPMC12743073

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.