ArticleAbdominal radiology (New York)2026
Study on the application value of histogram parameters from reduced field-of-view VOI in rectal cancer.
Article in Abdominal radiology (New York), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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3 authors.
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Abstract
purposeTo establish a reduced field-of-view (rFOV) DWI protocol on a 3.0T high-field MRI platform, explore the correlation between ADC histogram parameters derived from rFOV VOI and rectal cancer T/N staging, lymphatic vessel invasion, peripheral nerve invasion, histological differentiation, and Ki-67.
methodsProspectively included 47 pathologically confirmed rectal adenocarcinoma patients (March 2023-December 2024) for analyzing rFOV VOI histogram parameters. FireVoxel extracted ADC histogram parameters from tumor VOIs. Spearman correlation assessed relationships between parameters and T/N staging, lymphatic vessel / peripheral nerve invasion, histological differentiation, and Ki-67. ROC curves evaluated diagnostic efficacy.
resultsT-stage linked to Max, Min, Perc.1%, Perc.5%, Perc.10%, Perc.25% (P < 0.05); N-stage to Max, Min, Variance, Skewness, Kurtosis, Perc.99%; lymphatic vessel invasion to Max, Kurtosis, P99% (highest AUC: 0.773, combined diagnosis); peripheral nerve invasion to Max, Variance, Skewness, Kurtosis, Perc.95%, Perc.99% (highest AUC: 0.921, combined diagnosis); histological differentiation to Max, Variance, Skewness, Kurtosis, Perc.90%, Perc.95%, Perc.99% (highest AUC: 0.824, combined diagnosis); Ki-67 to Variance, Skewness, Perc.90%, Perc.95%, Perc.99% (highest AUC: 0.814, combined diagnosis). All P < 0.05.
conclusionsADC histogram analysis based on rFOV VOI reveals correlations between histogram parameters and pathological features of rectal cancer, highlighting their potential value as imaging biomarkers for staging and prognosis.
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