Evidence map›Paper›PMID 40601020›Full record

Trial reportEuropean journal of nuclear medicine and molecular imaging2025

Prognostic utility of

Sheng-Chieh Chan, Shu-Hang Ng, Chih-Hua Yeh, Yu-Chun Lin, Chien-Yu Lin, Jen-Hung Wang, Nai-Ming Cheng, Shih-Hsin Chen, Kai-Ping Chang, Jason Chia-Hsun Hsieh

Registry-linked trialAbstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03429868 (Prognostic Value of the Integrated PET/MRI in Patients With Nasopharyngeal Carcinoma), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03429868 nacompletednot on this map

Prognostic Value of the Integrated PET/MRI in Patients With Nasopharyngeal Carcinoma

TypeinterventionalSponsorChang Gung Memorial HospitalRan2015 to 2020Enrolled180ConditionsNasopharyngeal CarcinomaArmsintegrated PET/MRI
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sheng-Chieh ChanDepartment of Nuclear Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Shu-Hang NgDepartment of Diagnostic Radiology, Linkou Chang Gung Memorial Hospital, Chang Gung University, 333423, Taoyuan, Taiwan. shuhangng@gmail.com.ORCID 0000-0002-1842-6179
Chih-Hua YehDepartment of Diagnostic Radiology, Linkou Chang Gung Memorial Hospital, Chang Gung University, 333423, Taoyuan, Taiwan.
Yu-Chun LinDepartment of Diagnostic Radiology, Linkou Chang Gung Memorial Hospital, Chang Gung University, 333423, Taoyuan, Taiwan.
Chien-Yu LinDepartment of Radiation Oncology, Linkou Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, 333423, Taiwan.
Jen-Hung WangDepartment of Medical Research, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Nai-Ming ChengDepartment of Nuclear Medicine, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan.
Shih-Hsin ChenDepartment of Nuclear Medicine, Keelung Chang Gung Memorial Hospital, Keelung, Taiwan.
Kai-Ping ChangDepartment of Otorhinolaryngology, Linkou Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan.
Jason Chia-Hsun HsiehDivision of Hematology/Oncology, Department of Internal Medicine, Linkou Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan.

Funding

Buddhist Tzu Chi Medical Foundation TCMF-A 110- 03[114] and TCMF-A 110- 03[115]Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation TCRD113-035Ministry of Science and Technology NSC 104-2314-B-182A-084-MY3, 109-2314-B-303-015, 110-2314- B-303-014, and 111-2314-B-303-006
6 · The paper itself

Abstract

purposeIntravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) enhances tissue diffusion assessment by differentiating true molecular diffusion from microvascular perfusion, surpassing conventional DWI. This prospective study assessed the prognostic utility of

methodsWe prospectively enrolled 148 patients with primary NPC who underwent pretreatment PET/MRI. Quantitative parameters derived from IVIM-DWI, dynamic contrast-enhanced MRI (DCE-MRI), and

resultsIVIM-derived minimal true diffusion coefficient (D

conclusionIntegrated PET/MRI with IVIM imaging enables simultaneous quantification of water molecule diffusion, tumor microvascular perfusion, and glucose metabolism in NPC, yielding complementary imaging biomarkers that demonstrate superior prognostic value compared to conventional TNM staging.

trial registrationClinicalTrials.gov (NCT03429868), retrospectively registered on February 6, 2018.

Indexed as

Fluorodeoxyglucose F18Magnetic Resonance ImagingMotionNasopharyngeal CarcinomaNasopharyngeal NeoplasmsPositron-Emission TomographyAdultAgedCarcinomaDiffusion Magnetic Resonance ImagingFemaleHumansMaleMiddle AgedMultimodal ImagingPrognosisFluorodeoxyglucose F18Intravoxel incoherent motion diffusionNasopharyngeal carcinomaOverall survivalPositron emission tomography/Magnetic resonance imagingPrognosisRecurrence-free survival

Identifiers

PMID40601020

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.