Evidence map›Paper›PMID 40601012›Full record

Trial reportEuropean journal of applied physiology2025

Effects of simultaneous aerobic and inspiratory muscle training on diaphragm function, respiratory muscle strength, endurance, and fatigue index: randomized-controlled trial.

Zeliha Çelik, Nevin A Güzel, Seriyye Allahverdiyeva, Halit Nahit Şendur, Mahi Nur Cerit

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in European journal of applied physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06742372 (Effects of Combined Exercise Training Modality on Diaphragm Function and Performance), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06742372 naactive not recruitingnot on this map

Effects of Combined Exercise Training Modality on Diaphragm Function and Performance

TypeinterventionalSponsorGazi UniversityRan2023 to 2025Enrolled24ConditionsHealthy Individuals (Controls)Armscombined inspiratory and aerobic exercise training, aerobic exercise training
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zeliha ÇelikDepartment of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Amasya University, Amasya, Türkiye. zelihacelik1@hotmail.com.
Nevin A GüzelDepartment of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Gazi University, Ankara, Türkiye.ORCID http://orcid.org/0000-0003-0467-7310
Seriyye AllahverdiyevaDepartment of Radiology, Saf Hospital, Baku, Azerbaijan.ORCID http://orcid.org/0000-0001-6842-5978
Halit Nahit ŞendurDepartment of Radiology, Faculty of Medicine, Gazi University, Ankara, Türkiye.ORCID http://orcid.org/0000-0003-1690-2538
Mahi Nur CeritDepartment of Radiology, Faculty of Medicine, Gazi University, Ankara, Türkiye.ORCID http://orcid.org/0000-0003-2878-6052

Funding

Gazi University Scientific Research Projects Coordination Unit THD-2022-7771
6 · The paper itself

Abstract

purposeThis study aims to investigate the effects of Walking-Specific Inspiratory Muscle Training (W-SIMT) on diaphragm thickness-stiffness, pulmonary and respiratory muscle functions, and fatigue index. RESEARCH QUESTION: Do individuals who performed W-SIMT have better diaphragm functions, respiratory muscle strength, endurance, and performance?

methodsTwenty-seven healthy participants were included in the randomized-controlled study. The simultaneous inspiratory and aerobic exercise training (60-80% of maximal heart rate; 3 days/weeks; 4 weeks) was performed in the W-SIMT group (n = 14). The same aerobic (walking) exercise training protocol (n = 13) without Inspiratory Muscle Training (IMT) was applied in the walking (aerobic) group. The W-SIMT group performed 30 consecutive inspirations with 2-min rest (2 sets) in 50% of Maximal Inspiratory Pressure (MIP) using an assistive inspiratory muscle training device simultaneously while walking. The diaphragm thickness and stiffness, pulmonary functions, MIP, Maximal Expiratory Pressure (MEP), sustained inspiratory maximal pressure (P

resultsThere was a significant effect of group × time interaction for MIP (cmH₂O and %, respectively) (F = 28.719, p < 0.001; F = 10.640, p = 0.003), sum (Pmax) (F = 5.414, p = 0.029), and fatigue index (F = 4.775, p = 0.039), in favor of the W-SIMT group.

conclusionThe distinctive combination of respiratory muscle training and aerobic exercise shows additional benefits enhancing particularly respiratory and anaerobic performance even over a short period. Further studies are needed to explore the long-term effects of W-SIMT. TRIAL REGISTRY: Trial Registration Number: NCT06742372.

Indexed as

Breathing ExercisesDiaphragmExercisePhysical EnduranceRespiratory MusclesAdultFemaleHumansMaleMuscle FatigueMuscle StrengthWalkingAerobic exerciseAthletic performanceDiaphragmInspiratory muscle trainingPulmonary function tests

Identifiers

PMID40601012
PMCPMC12678587

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.