ArticleDevelopment (Cambridge, England)2025
Sex-converted testis somatic cells acquire female-specific behaviors and alter XY germline identity.
Article in Development (Cambridge, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Regulated apoptosis is a conserved mechanism pausing female reproduction and establishes the sterile worker caste in the eusocial wasp,bioRxiv : the preprint server for biology · 2026Article
- Somatic cells non-autonomously control germline incomplete cytokinesis through FGF signaling.bioRxiv : the preprint server for biology · 2026Article
- Stem cell competition.Current topics in developmental biology · 2026Review
- Post-transcriptional suppression of the pioneer factor Zelda protects the adult Drosophila testis from activation of the ovary program.PLoS biology · 2025Article
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Authors and funding
5 authors.
Funding
Abstract
Establishment and maintenance of cellular sex identity is essential for reproduction. Sex identity of somatic and germline cells must correspond for sperm or oocytes to be produced, with mismatched identity causing infertility in all organisms from flies to humans. In adult Drosophila testes, Chronologically inappropriate morphogenesis (Chinmo) is required for maintenance of male somatic identity. Loss of chinmo leads to feminization of the male soma, including adoption of female-specific cell morphologies and gene expression. However, the degree to which feminized somatic cells initiate female-specific cellular behaviors or influence the associated XY germline is unknown. Using extended live imaging, we find that chinmo-depleted somatic cells acquire cell behaviors characteristic of ovarian follicle cells, including incomplete cytokinesis and rotational migration. Importantly, migration in both contexts require the basement membrane protein Perlecan and the adhesion protein E-cadherin. Finally, we find that sex-converted somatic cells non-autonomously induce expression of an early oocyte specification protein in XY germ cells. Taken together, our work reveals a dramatic transformation of somatic cell behavior during sex conversion and provides a powerful model in which to study soma-derived induction of oocyte identity.
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