ArticleAnnals of clinical and translational neurology2025
Association of the ICH Score With Withdrawal of Life-Sustaining Treatment Over a 10-Year Period.
Article in Annals of clinical and translational neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Early care limitation after ICH in a population-based study: what drives clinicians' decisions?European stroke journal · 2026Article
- Association between ambient fine particulate matter and hemorrhagic stroke in Yancheng, China.Frontiers in public health · 2026Article
- Comparative study of the conservative and surgical treatment of spontaneous cerebellar hemorrhage.Frontiers in neurology · 2025Article
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16 authors.
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Abstract
objectiveThe intracerebral hemorrhage (ICH) score was developed to enhance provider communication and facilitate early severity assessment. We examined the association of the ICH score with mortality and withdrawal of life-sustaining treatment (WLST) in a large, multicenter stroke registry, and evaluated temporal trends in these associations.
methodsWe identified ICH patients from the Florida Stroke Registry from 2013 to 2022. Outcomes were WLST and in-hospital mortality. ICH scores were grouped as 0-2, 3-4, and 5-6. Importance plots identified key predictors of WLST. Model performance was assessed using AUC-ROC for logistic regression and random forest, adjusted for relevant confounders. Secondary analyses compared outcomes between 2015-2018 and 2019-2022 using stratified univariate logistic regression.
resultsIn total, 12,426 patients were included (mean age 69, 55% male, 56% white). The most predictive factors associated with WLST were ICH score, age, state region, presenting level of consciousness, insurance status, and race (RF AUC = 0.94, LR AUC = 0.82). Mortality was 6.6%, 41.5%, and 66% for ICH score 0-2, 3-4, and 5-6. WLST occurred more frequently in higher ICH score groups (OR 9.35 [95% CI: 8.5-10.3] for scores 3-4; OR 18.64 [95% CI: 15.28-22.74] for scores 5-6). Early WLST (< 48 h) was more common in higher score groups (OR 2.97 [95% CI: 2.48-3.55] for 3-4; OR 9.51 [95% CI: 7.33-12.35] for 5-6).
interpretationHigher ICH scores were strongly associated with mortality and WLST, including early withdrawal decisions. These associations remained largely consistent over time. These observational findings underscore the need for continued attention to how prognostic scores may influence WLST decisions.
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