Evidence map›Paper›PMID 40600656›Full record

ArticleFuture microbiology2025

Employing machine learning for identifying antifungal compounds against

Dienny Rodrigues de Souza, Lívia Do Carmo Silva, Kleber Santiago Freitas E Silva, Fabricio Silva de Jesus, Amanda Alves de Oliveira, Bruno Junior Neves, Maristela Pereira

Abstract read
In one paragraph

Article in Future microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dienny Rodrigues de SouzaLaboratory of Molecular Biology, Institute of Biological Sciences, Federal University of Goiás, Goiânia, Brazil.
Lívia Do Carmo SilvaLaboratory of Molecular Biology, Institute of Biological Sciences, Federal University of Goiás, Goiânia, Brazil.
Kleber Santiago Freitas E SilvaLaboratory of Molecular Biology, Institute of Biological Sciences, Federal University of Goiás, Goiânia, Brazil.
Fabricio Silva de JesusLaboratory of Cheminformatics, Faculty of Pharmacy, Federal University of Goiás, Goiânia, Brazil.
Amanda Alves de OliveiraLaboratory of Molecular Biology, Institute of Biological Sciences, Federal University of Goiás, Goiânia, Brazil.
Bruno Junior NevesLaboratory of Cheminformatics, Faculty of Pharmacy, Federal University of Goiás, Goiânia, Brazil.
Maristela PereiraLaboratory of Molecular Biology, Institute of Biological Sciences, Federal University of Goiás, Goiânia, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo evaluate the efficacy of a machine learning approach in developing classification and regression models for antifungal activity against MATERIALS &

methodsUtilized RF, SVM, and LightGBM algorithms to screen the eMolecules® library. Selected 17 virtual hits for in vitro assays.

resultsEleven compounds showed activity against C. albicans. Compounds 1 and 17 inhibited C. albicans at 0.51 µM and 0.071 µM, respectively.

conclusionsThe RF model proved effective for virtual screening, demonstrating the success of the physicochemical classification and regression model in identifying new antifungal molecules against C. albicans.

Indexed as

Antifungal AgentsCandida albicansMachine LearningAlgorithmsDrug Evaluation, PreclinicalHumansMicrobial Sensitivity TestsAntifungal Agentsantifungal activityCandida albicansclassification modelLightGBMmachine learningrandom forestregression modelsupport vector machine

Identifiers

PMID40600656
PMCPMC12320878

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.