Evidence map›Paper›PMID 40600645›Full record

ArticleFuture microbiology2025

Evaluation of a bivalent vaccine composed of iron scavenger receptors PMI1426 and PMI1945 against

Roghayeh Mohammadzadeh, Mehri Habibi, Mohammad Reza Asadi Karam

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Future microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Roghayeh MohammadzadehDepartment of Molecular Biology, Pasteur Institute of Iran, Tehran, Iran.
Mehri HabibiDepartment of Molecular Biology, Pasteur Institute of Iran, Tehran, Iran.
Mohammad Reza Asadi KaramDepartment of Molecular Biology, Pasteur Institute of Iran, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimUrinary tract infections (UTIs) caused by

methodsIn this study, vaccine candidates composed of PMI1426 and PMI1945 from

resultsSerum levels of IgG, IgG isotypes, IgA, and urinary IgA, as well as cytokine levels including IFN-γ, IL-4, and IL-17 were significantly elevated following vaccination with PMI1426 and PMI1945 as compared to the controls. The addition of alum enhanced the immune responses in both single and combined vaccine formulations. Furthermore, bacterial colonization in the bladder of mice challenged with

conclusionOur results support the development of a promising vaccine candidate against

Indexed as

Bacterial ProteinsBacterial VaccinesProteus InfectionsProteus mirabilisUrinary Tract InfectionsAdjuvants, ImmunologicAlum CompoundsAnimalsAntibodies, BacterialCytokinesFemaleHumansImmunogenicity, VaccineImmunoglobulin AImmunoglobulin GIronAdjuvants, ImmunologicAlum CompoundsAntibodies, BacterialBacterial ProteinsBacterial VaccinesCytokinesImmunoglobulin AImmunoglobulin GIronalumPMI1426PMI1945Proteus mirabilissubunit vaccineUrinary tract infection

Identifiers

PMID40600645
PMCPMC12320833

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.