ArticleInternational forum of allergy & rhinology2025
Extent of Resection and Role of Adjuvant Radiotherapy in Olfactory Neuroblastoma Without Definite Radiologic Evidence of Dural Invasion.
Article in International forum of allergy & rhinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Extent of Resection and Role of Adjuvant Radiotherapy in Olfactory Neuroblastoma Without Definite Radiologic Evidence of Dural Invasion.International forum of allergy & rhinology · 2025Article
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Abstract
objectivesTo evaluate the impact of the extent of resection and adjuvant radiotherapy (RT) on treatment outcomes in patients with early-stage olfactory neuroblastoma (ONB) without definite dural invasion.
methodsA retrospective review of ONB cases from two centers within a single institution between 1992 and 2023 was performed. Clinicopathologic data included tumor stage, grade, treatment modalities, margin status, follow-up time, and survival. Survival outcomes, including overall survival (OS), disease-free survival (DFS), and local recurrence-free survival (LFS), were analyzed.
resultsOf 118 ONB patients, 38 were included in the final cohort, with most (76.3%) classified as modified Kadish (mKadish) stage A or B. The 10-year DFS and LFS rates were 68.5% and 89.7%, respectively. No local recurrence occurred in patients who underwent transdural resection with negative margins, regardless of adjuvant RT. Extradural resection with adjuvant RT significantly improved LFS compared to extradural resection alone (log-rank p = 0.032). Pathologic dura involvement was identified in four (19.0%) of 21 patients who underwent transdural resection. No significant difference in oncologic outcomes between unilateral and bilateral resections was observed when transdural resection was performed for unilateral disease.
conclusionsTransdural resection with negative surgical margins, regardless of adjuvant RT, or extradural resection with adjuvant RT, demonstrated excellent local control. Extradural resection alone was associated with a higher risk of local recurrence. Unilateral transdural resection can be feasible for unilateral disease.
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