Evidence map›Paper›PMID 40600557›Full record

ArticleCurrent medicinal chemistry2026

Synthesis of (E)-3-(aryl)-1-phenylprop-2-en-1-one Chalcone Derivatives for Hyperglycemic Effect in Diabetes:

Muhammad Siddiq, Basharat Ali, Saeed Ullah, Sobia Ahsan Halim, Zunaira Rehman, Naveed Muhammad, Muhammad Riaz, Nusrat Hussain, Mehreen Ghufran, Iffat Akbar and 3 more

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Article in Current medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Muhammad SiddiqDepartment of Pharmacy, Abdul Wali Khan University, Mardan, KPK, Pakistan.
Basharat AliSulaiman Bin Abdullah Aba Al-Khail - Center for Interdisciplinary Research in Basic Science (SA-CIRBS), International Islamic University, Islamabad, Pakistan.
Saeed UllahNatural and Medical Sciences Research Center, University of Nizwa, PO Box 33, 616 Birkat Al Mauz, Nizwa, Oman.
Sobia Ahsan HalimNatural and Medical Sciences Research Center, University of Nizwa, PO Box 33, 616 Birkat Al Mauz, Nizwa, Oman.
Zunaira RehmanSulaiman Bin Abdullah Aba Al-Khail - Center for Interdisciplinary Research in Basic Science (SA-CIRBS), International Islamic University, Islamabad, Pakistan.
Naveed MuhammadDepartment of Pharmacy, Abdul Wali Khan University, Mardan, KPK, Pakistan.
Muhammad RiazSulaiman Bin Abdullah Aba Al-Khail - Center for Interdisciplinary Research in Basic Science (SA-CIRBS), International Islamic University, Islamabad, Pakistan.
Nusrat HussainDepartment of Chemistry, University of Baltistan, Skardu, Pakistan.
Mehreen GhufranDepartment of Pathology, MTI Bacha Khan Medical College Mardan, KPK, Pakistan.
Iffat AkbarDepartment of Pharmacy, Abdul Wali Khan University, Mardan, KPK, Pakistan.
Magda H AbdellattifDepartment of Chemistry, College of Science, Taif University, P.O. Box 11099, Taif, 21944, Saudi Arabia.
Ajmal KhanNatural and Medical Sciences Research Center, University of Nizwa, PO Box 33, 616 Birkat Al Mauz, Nizwa, Oman.
Ahmed Al-HarrasiNatural and Medical Sciences Research Center, University of Nizwa, PO Box 33, 616 Birkat Al Mauz, Nizwa, Oman.

Funding

Taif University Saudi Arabia TU-DSPP-2024-19The Oman Research Council (TRC) BFP/RGP/HSS/23/037)
6 · The paper itself

Abstract

backgroundDiabetes mellitus (DM) is a chronic metabolic disorder that seeks treatment instead of available mitigative therapy.

methodsSix (E)-3-(aryl)-1-phenylprop-2-en-1-one chalcones were synthesized and characterized through various spectroscopic techniques. Their anti-diabetic potential was examined through in vitro (α-glucosidase and α-amylase inhibition assays), in vivo (alloxan-induced hyperglycemia), and in silico studies.

resultsAll the chalcones derivatives significantly inhibited α-glucosidase and α-amylase. Compounds 11 (IC

conclusionThese results demonstrate that all these molecules have significant anti-diabetic potential.

Indexed as

ChalconesDiabetes Mellitus, ExperimentalGlycoside Hydrolase InhibitorsHyperglycemiaHypoglycemic Agentsalpha-Amylasesalpha-GlucosidasesAnimalsBlood GlucoseHumansMaleMolecular Docking SimulationMolecular StructureRatsStructure-Activity Relationshipalpha-Amylasesalpha-GlucosidasesBlood GlucoseChalconesGlycoside Hydrolase InhibitorsHypoglycemic Agentsanti-diabetic activitiesB-cells.chalcone derivativesSynthesisα-amylaseα-glucosidase inhibition

Identifiers

PMID40600557

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.