ArticleJournal of the International AIDS Society2025
Awareness and intention to use event-driven and long-acting injectable pre-exposure prophylaxis among adolescent and young men who have sex with men and transgender women in Brazil: a cross-sectional study.
Article in Journal of the International AIDS Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Family-Based Discrimination, Non-disclosure of Sexual Orientation or Gender identity, and Initiation of Oral Pre-exposure Prophylaxis Among Adolescents.AIDS and behavior · 2026Article
- PrEP uptake, persistence, and patterns of choice dynamics between oral and long-acting injectable with cabotegravir among sexually and gender-diverse adolescents in Brazil: a multisite cohort implementation study.Lancet regional health. Americas · 2026Article
- A turning point for youth HIV care in the United States: tailored strategies for adolescents and young adults.Critical public health · 2026Article
- Awareness and acceptability of long-acting injectable pre-exposure prophylaxis for HIV prevention among female students at tertiary learning institutions: a multi-center, institution-based cross-sectional study.BMC public health · 2025Article
- Expanding access to a choice-based multi-method PrEP market for HIV prevention.Journal of the International AIDS Society · 2025Article
- Article
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Authors and funding
6 authors.
Funding
Abstract
introductionNew pre-exposure prophylaxis (PrEP) options, including event-driven and long-acting injectable, may enhance HIV prevention strategies among adolescents and youth. This study examined awareness and intention to use event-driven and long-acting injectable PrEP, along with associated factors, among adolescent and young men who have sex with men and transgender women.
methodsA cross-sectional study was conducted between December 2020 and February 2022 among men who have sex with men and young transgender women aged 15-20 years, who participated in a daily oral PrEP cohort study in Salvador and São Paulo, Brazil. Binomial logistic regression models analysed factors associated with the intention to use event-driven and long-acting injectable PrEP.
resultsA total of 1221 participants were enrolled in the cohort at the time of this analysis, with 597 responding to the survey. Awareness of event-driven and long-acting injectable PrEP was reported by 15.3% and 18.0% of participants, respectively. Intention to use event-driven PrEP was reported by 56.4% of participants, while 81.5% expressed intention to use long-acting injectable PrEP. Participants with lower and moderate adherence to daily oral PrEP were more likely to intend to use event-driven PrEP (OR = 1.79; 95% CI: 1.04-3.08), whereas those who reported always or often using condoms in insertive anal sex with steady or casual partners were less likely to intend to use event-driven PrEP (OR = 0.37; 95% CI: 0.15-0.90). For long-acting injectable PrEP, participants with middle (OR = 1.93; 95% CI: 1.05-3.53) or low socio-economic status (OR = 3.13; 95% CI: 1.30-7.51) and those reporting three or more casual partners in the past 3 months (OR = 2.25; 95% CI: 1.30-3.89) were more likely to intend to use long-acting injectable PrEP. Conversely, participants who had never used daily oral PrEP were less likely to intend to use long-acting injectable PrEP (OR = 0.31; 95% CI: 0.11-0.92).
conclusionsAdolescents and young people in Brazil demonstrated a stronger preference for long-acting injectable over event-driven PrEP, with sexual behaviour patterns significantly influencing choices. Expanding prevention options may enhance PrEP uptake and adherence, improving HIV prevention strategies among adolescents and young adults.
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