ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Gompertz Law-Based Biological Age (GOLD BioAge): A Simple and Practical Measurement of Biological Ageing to Capture Morbidity and Mortality Risks.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Iron status from diet and serum in relation to biological aging acceleration: A NHANES cross-sectional study.Asia Pacific journal of clinical nutrition · 2026Article
- Age-dependent prognostic value of biological age for metastasis and survival in gastrointestinal cancer.Scientific reports · 2026Article
- Stress-hyperglycemia ratio, its longitudinal trajectories, and stress-metabolism synergy in predicting cardiometabolic multimorbidity: A nationwide prospective cohort study.The Journal of international medical research · 2026Observational
- [Application of biological age for cardiovascular risk prediction in a community-based Chinese cohort].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2026Article
- Biological age acceleration, genetic susceptibility, and incident diabetic retinopathy risk: A prospective cohort study.The journal of nutrition, health & aging · 2026Article
- Biological age acceleration in primary aldosteronism: associations with renin, aldosterone, aldosterone-to-renin ratio, and left ventricular mass index.Journal of hypertension · 2026Article
- Longitudinal associations of cumulative and repeated-measure patterns of insulin resistance surrogate indices with biological age acceleration and incident cardiovascular disease across cardiovascular-kidney-metabolic syndrome stages 0-3: evidence from CHARLS 2011-2020.Cardiovascular diabetology · 2026Article
- sc-ChromAging: A Single-Cell Chromatin Accessibility-based Clock Decodes Cell-Type-Specific Epigenetic Aging Trajectories.npj aging · 2026Article
- Divergent impacts of estradiol/testosterone reduction on biological aging: optimal HRT window in females recommended.Biology of sex differences · 2026Article
- Association of various insulin resistance surrogate indices with aging acceleration and future risk of cardiovascular disease in individuals with cardiovascular-kidney-metabolic syndrome stages 0-3: insights from CHARLS 2011-2020 data.Cardiovascular diabetology · 2026Article
- Longitudinal associations of sarcopenia and biological age acceleration with rate of cognitive decline.BMC public health · 2026Article
- A Commentary on "Accelerated biological aging and postoperative acute kidney injury in surgical patients".International journal of surgery (London, England) · 2026Article
- Association of smoking behaviors with GOLD biological age acceleration and potential mediation: Evidence from NHANES 1999-2023.Tobacco induced diseases · 2026Article
- Early-life nutritional deprivation and multimorbidity in middle- aged and older adults: a longitudinal exploratory mediation analysis of biological aging.Frontiers in nutrition · 2026Article
- Development of Age- and Sex-Specific Metabolomics-Based Biological Ageing Clocks for 10-Year Mortality Prediction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A Residual Approach to Estimate Biological Age from Gompertz Modeling.medRxiv : the preprint server for health sciences · 2025Article
- From ageing clocks to human digital twins in personalising healthcare through biological age analysis.NPJ digital medicine · 2025Article
- Gompertz Law-Based Biological Age (GOLD BioAge): A Simple and Practical Measurement of Biological Ageing to Capture Morbidity and Mortality Risks.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
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15 authors.
Funding
Abstract
Biological age reflects actual ageing and overall health, but current ageing clocks are often complex and difficult to interpret, which limits their clinical application. This study introduces a Gompertz law-based biological age (GOLD BioAge) model designed to simplify the assessment of ageing. We calculated GOLD BioAge using clinical biomarkers and found significant associations between the difference from chronological age (BioAgeDiff) and the risks of morbidity and mortality in the NHANES and UK Biobank. Using proteomics and metabolomics data, we developed GOLD ProtAge and MetAge, which outperformed the clinical biomarker models in predicting mortality and chronic disease risk in UK Biobank. Benchmark analyses demonstrated that the models outperformed common ageing clocks in predicting mortality across diverse age groups in both the NHANES and UK Biobank cohorts. Additionally, a simplified version called Light BioAge is created, which uses three biomarkers to assess ageing. The Light model reliably captured the mortality risk across three validation cohorts (CHARLS, RuLAS, and CLHLS). It significantly predicted the onset of frailty, stratified frail individuals, and collectively identified individuals at high risk of mortality. In summary, the GOLD BioAge algorithm provides a valuable framework for the assessment of ageing in public health and clinical practice.
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