Evidence map›Paper›PMID 40600309›Full record

ArticleJournal of psychosomatic obstetrics and gynaecology2025

Psychophysical correlates of labor pain intensity and unpleasantness.

Lee-Kai Sun, Lia M Farrell, Kelsea R LaSorda, Robert T Krafty, Grace Lim

Abstract read
In one paragraph

Article in Journal of psychosomatic obstetrics and gynaecology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lee-Kai SunDepartment of Anesthesiology & Perioperative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-2441-8407
Lia M FarrellDepartment of Anesthesiology & Perioperative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Kelsea R LaSordaDepartment of Anesthesiology & Perioperative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Robert T KraftyDepartment of Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Grace LimDepartment of Anesthesiology & Perioperative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-8013-0080

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR001857 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2016 to 2025
$129.3M
Optimizing the use of ketamine to reduce chronic postsurgical painUH3CA261067 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DOAN, LISA, WANG, JING · 2021 to 2024
$5.2M
Ketamine to reduce postpartum depression and pain after cesarean deliveryR01MH134538 · NIMH · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Grace Lim · 2023 to 2026
$2.3M
NCATS NIH HHS UL1 TR001857NCI NIH HHS UH3 CA261067NIMH NIH HHS R01 MH134538
6 · The paper itself

Abstract

The neurobiological mechanisms linking perinatal pain and mood disorders remain unclear. Emotional dimensions of labor pain, particularly unpleasantness, may reflect engagement of limbic pathways shared with affective disorders. This study examined whether prenatal quantitative sensory testing (QST) parameters are associated with the sensory and emotional dimensions of labor pain. Healthy primiparous women were enrolled and followed from third trimester through delivery. Prenatal QST assessed mechanical and thermal thresholds, tolerances, and temporal summation. Labor pain was recorded hourly using a validated electronic diary. Univariable linear regression evaluated relationships between QST measures and labor pain outcomes. Of 164 participants completing QST, , 55 had complete labor pain diaries. Prenatal QST parameters were associated with emotional, but not sensory, aspects of labor pain. Pain unpleasantness was associated with average heat threshold (Coefficient = 40.3, SE = 17.2,

Indexed as

EmotionsLabor PainPain ThresholdAdultFemaleHumansPain MeasurementPregnancyYoung Adultcentral sensitizationlabor painpain unpleasantnessQSTQuantitative sensory testing

Identifiers

PMID40600309
PMCPMC12352576

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.