Evidence map›Paper›PMID 40600308›Full record

Trial reportJournal of neurotrauma2025

A High Omega-3, Low Omega-6 Diet Reduces Headache Frequency and Intensity in Persistent Post-Traumatic Headache: A Randomized Trial.

Daisy Zamora, Kimbra Kenney, Mark Horowitz, Wesley R Cole, Beth A MacIntosh, Jacques P Arrieux, Margaret Dunlap, Olafur S Palsson, Cora Davis, Carol B Moore and 9 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of neurotrauma, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Daisy ZamoraDepartment of Physical Medicine & Rehabilitation, University of North Carolina, Chapel Hill, North Carolina, USA.
Kimbra KenneyDepartment of Neurology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
Mark HorowitzLipid Peroxidation Unit, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.ORCID 0000-0002-0061-8586
Wesley R ColeDepartment of Exercise and Sport Science, University of North Carolina, Chapel Hill, North Carolina, USA.
Beth A MacIntoshMetabolic and Nutrition Research Core, University of North Carolina Health, Chapel Hill, North Carolina, USA.
Jacques P ArrieuxDepartment of Brain Injury Medicine, Intrepid Spirit Center, Womack Army Medical Center, Fort Bragg, North Carolina, USA.
Margaret DunlapDepartment of Neurology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
Olafur S PalssonDepartment of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA.
Cora DavisHenry M. Jackson Foundation in support of Uniformed Services University at the National Intrepid Center of Excellence, Bethesda, Maryland, USA.
Carol B MooreDepartment of Neurology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
Wanda RiveraHenry M. Jackson Foundation in support of Uniformed Services University at the National Intrepid Center of Excellence, Bethesda, Maryland, USA.
J Kent WernerDepartment of Neurology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.ORCID 0000-0001-9858-2931
Ramon Diaz-ArrastiaPerelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Anthony F DomenichielloOffice of Pain Policy and Planning, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.
Pranavi NaraSidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Ameer Y TahaDepartment of Food Science and Technology, College of Agriculture and Environmental Sciences, University of California, Davis, California, USA.
Duncan A SylvestreDepartment of Food Science and Technology, College of Agriculture and Environmental Sciences, University of California, Davis, California, USA.
Chris E RamsdenLipid Peroxidation Unit, Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
Keturah R FaurotDepartment of Physical Medicine & Rehabilitation, University of North Carolina, Chapel Hill, North Carolina, USA.

Funding

Intramural NIH HHS Z99 AG999999
6 · The paper itself

Abstract

Targeted manipulation of dietary omega-3 and omega-6 fatty acids has previously been shown to decrease nontraumatic headaches in controlled trials. This study assessed the effects of a diet high in omega-3 fatty acids and low in omega-6 linoleic acid (H3L6 diet) on headache frequency and severity, headache impact, and plasma nociceptive mediators in a persistent post-traumatic headache (pPTH) population. One hundred and twenty-two participants with pPTH were randomized 1:1 to 12 weeks of either the H3L6 (

Indexed as

Fatty Acids, Omega-3Fatty Acids, Omega-6Post-Traumatic HeadacheAdultFemaleHumansMaleMiddle AgedTreatment OutcomeYoung AdultFatty Acids, Omega-3Fatty Acids, Omega-6clinical trialomega-3 fatty acidsomega-6 fatty acidsoxylipinspersistent post-traumatic headachestraumatic brain injury

Identifiers

PMID40600308
PMCPMC12413749

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.