Evidence map›Paper›PMID 40600180›Full record

ArticleMaterials today. Bio2025

Nanoencapsulation platform for oral delivery of peptides: In vitro stabilization of AvPAL and formulation of a gastrointestinal-resistant luciferase.

Daniel Abella-López, Adrián López-Teijeiro, Tomás Pose-Boirazian, Natalia Barreiro-Piñeiro, José M Martínez-Costas

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Daniel Abella-LópezDepartment of Biochemistry and Molecular Biology and Center for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, C/ Jerónimo de la Fuente S/N, 15782, Santiago de Compostela, Spain.
Adrián López-TeijeiroDepartment of Biochemistry and Molecular Biology and Center for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, C/ Jerónimo de la Fuente S/N, 15782, Santiago de Compostela, Spain.
Tomás Pose-BoirazianDepartment of Biochemistry and Molecular Biology and Center for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, C/ Jerónimo de la Fuente S/N, 15782, Santiago de Compostela, Spain.
Natalia Barreiro-PiñeiroDepartment of Biochemistry and Molecular Biology and Center for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, C/ Jerónimo de la Fuente S/N, 15782, Santiago de Compostela, Spain.
José M Martínez-CostasDepartment of Biochemistry and Molecular Biology and Center for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, C/ Jerónimo de la Fuente S/N, 15782, Santiago de Compostela, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phenylketonuria (PKU) is a genetic metabolic disorder caused by an enzyme deficiency that leads to the accumulation of phenylalanine, which can cause neurotoxicity and several other problems. A potential alternative to the universal standard treatment based on a lifelong protein-restricted diet, is the development of oral replacement therapies using phenylalanine ammonia lyase from

Indexed as

AvPALEnzyme replacement therapyGastrointestinal resistanceIC-TaggingOral peptide deliveryPhenylketonuriaProtein stabilization

Identifiers

PMID40600180
PMCPMC12212289

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.