ArticleMaterials today. Bio2025
Curcumin-loaded nanoparticles for renal ischemia-reperfusion injuries: Triple-play of redox homeostasis accommodation, lipid metabolism regulation, and nuclear magnetic tracing.
Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Advances in the Targeted Drug Delivery System for Renal Fibrosis.International journal of nanomedicine · 2026Review
- Plant metabolites: potential treatments for ischemic acute kidney injury.Frontiers in pharmacology · 2026Review
- Layered Double Hydroxide-Loaded Dl-3-n-Butylphthalide Alleviates Renal Ischemia-Reperfusion Injury by Regulating the PI3K-AKT-Nrf2 Signaling Pathway.International journal of nanomedicine · 2026Article
- Ferroptosis in Human Diseases: Fundamental Roles and Emerging Therapeutic Perspectives.Antioxidants (Basel, Switzerland) · 2025Review
Corrections and comments
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Authors and funding
8 authors.
Funding
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Abstract
Renal ischemia reperfusion (RI/R) injury is a significant pathological process that occurs in acute kidney injury (AKI), and is associated with high mortality rates and poor prognoses. It is therefore essential to explore new therapeutic strategies to enhance treatment outcomes for this condition. Curcumin (Cur), a natural bioactive polyphenolic compound, possesses anti-inflammatory and antioxidant properties. However, its clinical application is limited by poor water solubility and low bioavailability. To overcome these challenges, two amphiphilic molecules were synthesized, PEG-DTPA-DA (PD) and Gd-DTPA-N10 (G). By self-assembling PD and G while loading Cur, a nanoparticle was successfully prepared, PDG@Cur, which served three functions: regulation of lipid metabolism, maintenance of redox homeostasis, and function as a nuclear magnetic resonance (NMR) tracer.
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