ArticleMaterials today. Bio2025
3D bioprinting of a perfusable skin-on-chip model suitable for drug testing and wound healing studies.
Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Recent advances in immunocompetent human skin-on-chip models: Construction strategies and biomedical applications.Bioactive materials · 2026Review
- Pharmacokinetic Relevance of In Vitro Skin Models: Absorption, Cutaneous Distribution, Metabolism, and Clearance-like Removal in Dermal and Transdermal Drug Testing.Pharmaceutics · 2026Review
- Next-generation skin wound healing related disease models with integration of immune cells.Protein & cell · 2026Review
- Amniotic Membrane-Derived Factors in Immunomodulation and Regenerative Medicine: Current Evidence and Emerging Perspectives in Biomaterials and 3D Bioprinting.Journal of functional biomaterials · 2026Review
- Research Progress on Construction Technology of 3D Human Skin Models and Its Application Prospects in Dermatology.International journal of molecular sciences · 2026Review
- Bioprinted Recombinant Human-Collagen-Based In Vitro Skin Models for Assessing Effects of Nano-ZnO on Dermis.Gels (Basel, Switzerland) · 2025Article
- 3D bioprinting bone/cartilage organoids: construction, applications, and challenges.Journal of orthopaedic translation · 2025Review
- Engineering an Injectable Scaffold with Enhanced ECM Mimicry for Cell Delivery and Tissue Regeneration.ACS biomaterials science & engineering · 2025Article
- From 1D microbiological assays to 3D advanced skin models: enhancing preclinical strategies to unravel the impact of bioactive textiles on the human skin microbiome.Frontiers in cellular and infection microbiology · 2025Review
- 3D bioprinting of skin equivalents: Towards functional wound healing models.Journal of tissue engineeringReview
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The skin, as the body's largest organ, serves critical functions including physical protection, thermoregulation, sensation, and immunity, making it a key focus in tissue engineering. Recently, 3D bioprinting has emerged as a promising method for fabricating skin substitutes, offering potential applications in both drug testing and clinical treatments for severe skin injuries. This technology enables the precise deposition of cells within a biomaterial matrix to create complex tissue structures with controlled microenvironments. A major challenge in 3D bioprinted skin models is incorporating a vascular system for adequate nutrient and oxygen distribution. Here, we present a novel approach for creating a perfusable 3D vascularized skin model using two bioinks: gelatin methacryloyl (GelMA) for the dermal and epidermal layers and Pluronic F127 as a sacrificial material for vascular channel formation. This method integrates three cell types, neonatal foreskin fibroblasts, human epidermal keratinocytes, and human umbilical vein endothelial cells, to establish a biomimetic skin construct. By employing sacrificial bioprinting techniques, we successfully developed a skin model with vascularized structures that can be used for advanced
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.