ArticleInternational journal of general medicine2025
Combined Predictive Value of Neutrophil-to-Lymphocyte Ratio and CHA2DS2-VASc Score for Cardiogenic Cerebral Embolism in NVAF Patients.
Article in International journal of general medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Systemic Inflammation Mediates the Association Between Atrial Fibrillation and Functional Outcomes After Ischemic Stroke.Journal of inflammation research · 2026Article
- The interactive effect of sex and neutrophil-to-lymphocyte ratio on short-term poor outcomes in patients with nonvalvular atrial fibrillation-related acute cardioembolic stroke.European journal of medical research · 2025Article
- Exploring Left Atrial Appendage Thrombi in Large Vessel Occlusion Stroke by Cardiac CT: Thrombus Features, LAA Characteristics and the Impact of Direct Oral Anticoagulation.Neurology international · 2025Article
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5 authors.
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Abstract
Aim: This study aimed to determine the identification role of neutrophil-to-lymphocyte ratio (NLR) combined with CHA2DS2-VASC score for cardiogenic cerebral embolism (CCE) in acute ischemic stroke patients with non-valvular atrial fibrillation (NVAF). Methods: From January 2019 to August 2024, a total of 402 acute ischemic stroke patients with NVAF were enrolled in this retrospective study and were divided according to the occurrence of CCE into the CCE or non-CCE groups. Clinical data were collected from both groups, which included demographic data, medical history, CHA2DS2-VASC score, and laboratory tests (blood cell counts and blood biochemistry indicators). A predictive model based on blood indexes and the CHA2DS2-VASC score was constructed using least absolute shrinkage and selection operator (LASSO) regression analysis. Results: Multiple regression analysis showed that the CHA2DS2-VASc score (OR = 2.95, 95% CI = 2.19-3.99, p < 0.001), white blood count (OR = 1.43, 95% CI = 1.15-1.78, p = 0.001), neutrophil-to-lymphocyte ratio (NLR; OR = 1.63, 95% CI = 1.29-2.05, p < 0.001), and D-dimer levels (OR = 1.56, 95% CI = 1.15-2.12, p = 0.005) were independent risk factors for CCE. Spearman correlation analysis showed that NLR and the CHA2DS2-VASc score had a significant positive correlation (R = 0.449, p < 0.001). The area under the receiver operating characteristic (ROC) curve (AUC) for NLR and the CHA2DS2-VASc score were 0.869 (95% CI = 0.843-0.901) and 0.859 (95% CI = 0.820-0.898), respectively. A composite index for distinguishing CCE risk was constructed using LASSO regression analysis, which yielded an AUC value of 0.924 (95% CI = 0.898-0.950). Conclusion: NLR is an independent risk factor for CCE in NVAF patients, and combining it with CHA2DS2-VASC score provides a more useful composite index for identifying the CCE risk of patients with NVAF. This composite score may serve as a promised tool in clinical workflows, and it could even contribute to individualized anticoagulation strategies by identifying high-risk patients who may benefit from more positive preventive methods.
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