ArticleRadiology case reports2025
Malignant peripheral nerve sheath tumor of the shoulder: A rare case highlighting the role of multimodal management.
Article in Radiology case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Malignant peripheral nerve sheath tumors (MPNSTs) are rare and aggressive sarcomas often associated with neurofibromatosis type 1 (NF1) or prior radiation therapy. We report the case of a 26-year-old male who presented with a rapidly enlarging, painful mass in the left shoulder initially misdiagnosed as an abscess. MRI revealed a large extra-compartmental lesion with heterogeneous enhancement infiltrating the trapezius muscle. Histopathology confirmed MPNST, showing high mitotic activity (16/10 HPF), 10% necrosis, and a Ki-67 index of 40%, with diffuse Sox10 and focal S100 positivity. The patient received neoadjuvant radiotherapy followed by complete surgical excision and defect reconstruction using a pedicled trapezius flap and a split-thickness skin graft. This case highlights the importance of early imaging, multidisciplinary planning, and multimodal treatment in the management of MPNSTs.
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