ArticleCureus2025
Methotrexate vs. Surgery in the Management of Ectopic Pregnancy: A Comparative Analysis of Treatment Outcomes.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Article
- Clinical Profile of Ectopic Pregnancy in a Tertiary Care Center: A Five-Year Retrospective Study.JNMA; journal of the Nepal Medical Association · 2026Observational
- Clinical Management and Outcomes of Ectopic Pregnancies: Experience From Sohar Hospital Over Three Years.Cureus · 2025Article
- Article
- After the Shock: Impact of Ectopic Pregnancy on Subsequent Fertility and Parenthood.Biomedicines · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMethotrexate (MTX) is a non-invasive alternative to surgery for ectopic pregnancy, a condition in which a fertilized egg implants outside the uterine cavity and poses serious hazards to the mother.
objectiveThis study aimed to compare the effectiveness, safety, and reproductive outcomes of MTX versus surgical intervention in the management of ectopic pregnancy. METHODOLOGY: A two-year comparative study was conducted from 2022 to 2024, with 260 women diagnosed with unruptured ectopic pregnancies. Participants were randomized to either the surgical group (n = 130) or the MTX group (n = 130). The surgical group had either open or laparoscopic surgery, and MTX was given as a single dose. In addition to gathering laboratory, clinical, and demographic data, patients were monitored for three months. IBM SPSS Statistics for Windows, Version 26 (Released 2019; IBM Corp., Armonk, New York, United States) was used for statistical analysis.
resultsOne hundred twenty-eight out of 130 patients (98.46%) in the surgical group had a successful course of therapy, while 114 out of 130 patients (87.69%) in the MTX group saw a favorable result (p=0.001). With a mean hospital stay of 1.2 ± 0.5 days, the MTX group had fewer problems than the surgical group, which saw a mean hospital stay of 3.0 ± 1.2 days (p<0.001). In terms of reproductive outcomes, 95 out of 130 patients (73.08%) in the surgical group and 89 out of 130 patients (68.46%) in the MTX group went on to get pregnant intrauterine (p=0.56).
conclusionSurgery has a greater success rate than MTX when it comes to treating ectopic pregnancy, but MTX has benefits in terms of hospital stay and recuperation after surgery. Treatment decisions need to be tailored to each patient's unique clinical situation.
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Registered trials
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