Evidence map›Paper›PMID 40599999›Full record

ArticleJournal of molecular and cellular cardiology plus2025

Characterization of human living myocardial slices culture-induced adaptations: a translational perspective.

Jort S A van der Geest, Ernest Diez Benavente, Willem B van Ham, Pieter A Doevendans, Linda W van Laake, Teun P de Boer, Vasco Sampaio-Pinto, Joost P G Sluijter

Abstract read
In one paragraph

Article in Journal of molecular and cellular cardiology plus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. iScience · 2026
    Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jort S A van der GeestDepartment of Cardiology and Experimental Cardiology Laboratory, Division of Heart & Lungs, University Medical Centre Utrecht, Utrecht, the Netherlands.
Ernest Diez BenaventeDepartment of Cardiology and Experimental Cardiology Laboratory, Division of Heart & Lungs, University Medical Centre Utrecht, Utrecht, the Netherlands.
Willem B van HamDepartment of Medical Physiology, Division of Heart & Lungs, University Medical Centre Utrecht, Utrecht, the Netherlands.
Pieter A DoevendansDepartment of Cardiology and Experimental Cardiology Laboratory, Division of Heart & Lungs, University Medical Centre Utrecht, Utrecht, the Netherlands.
Linda W van LaakeDepartment of Cardiology and Experimental Cardiology Laboratory, Division of Heart & Lungs, University Medical Centre Utrecht, Utrecht, the Netherlands.
Teun P de BoerDepartment of Medical Physiology, Division of Heart & Lungs, University Medical Centre Utrecht, Utrecht, the Netherlands.
Vasco Sampaio-PintoDepartment of Cardiology and Experimental Cardiology Laboratory, Division of Heart & Lungs, University Medical Centre Utrecht, Utrecht, the Netherlands.
Joost P G SluijterDepartment of Cardiology and Experimental Cardiology Laboratory, Division of Heart & Lungs, University Medical Centre Utrecht, Utrecht, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heart failure involves complex pathophysiological processes, best studied in multicellular human cardiac tissues that reflect the native cellular composition and microenvironment. However, maintaining primary cells and tissues in culture for extended periods remains challenging. Developing robust human cardiac models is critical for advancing preclinical research and bridging the gap to clinical applications. This study aims to characterize adaptations occurring in human living myocardial slices (LMS) during

Indexed as

Biomimetic cultureCardiac functionDrug developmentLiving myocardial slicesRemodelingTranslational research

Identifiers

PMID40599999
PMCPMC12212253

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.