Evidence map›Paper›PMID 40599994›Full record

SynthesisFrontiers in pain research (Lausanne, Switzerland)2025

Low-intensity focused ultrasound of the spine in the treatment of chronic pain and movement disorder: a scoping review.

Kyung Seol, Brian Hong, Nicolas Kelhofer, Suguna Pappu, Michael Oelze

Abstract readSystematic Review
In one paragraph

Synthesis in Frontiers in pain research (Lausanne, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kyung SeolCarle Illinois College of Medicine, University of Illinois at Urbana-Champaign, Champaign, IL, United States.
Brian HongCarle Illinois College of Medicine, University of Illinois at Urbana-Champaign, Champaign, IL, United States.
Nicolas KelhoferCarle Illinois College of Medicine, University of Illinois at Urbana-Champaign, Champaign, IL, United States.
Suguna PappuCarle Illinois College of Medicine, University of Illinois at Urbana-Champaign, Champaign, IL, United States.
Michael OelzeBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, IL, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Low-Intensity Focused Ultrasound Stimulation (LIFU) is a noninvasive and nondestructive neuromodulatory method with growing evidence for the safe and effective treatment of chronic pain. However, the effect of LIFU applied to the spine region, including the spinal cord and dorsal root ganglia, is not well understood. In this work, we review current advances in LIFU of the spine region for the treatment of chronic neuropathic pain and movement disorders to explore potential clinical applications and indicate a direction for future study. To assess the current state of LIFU application to pain modulation over the spinal cord region, a systematic search was performed according to PRISMA guidelines using PubMed, Web of Science, Scopus, and citation matching through December 17, 2024. Inclusion criteria were English language, non-tissue-damaging ultrasound neuromodulation, intervention over the spinal cord region, and relation to neuropathic pain. Exclusion criteria were existing review papers, extracorporeal shockwave therapy, tissue-destructive ultrasound treatments, non-focused ultrasound, and

Indexed as

chronic neuropathic paindorsal root ganglia (DRG)focused ultrasound (FUS)low intensity focused ultrasound (LIFU)movement disordersneuromodulationnoninvasive pain treatmentspinal cord

Identifiers

PMID40599994
PMCPMC12209223

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.