ArticleBioinformation2025
Molecular docking analysis of tyrosinase with compounds from poly-herbal formulation for vitiligo treatment.
Article in Bioinformation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Ultrasound-assisted deep eutectic solvent extraction of tyrosinase inhibitors from lotus seed peel powder.Ultrasonics sonochemistry · 2026Article
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6 authors.
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Abstract
Vitiligo is an acquired depigmentary disorder caused by the absence of melanocytes, affecting 0.1% to 2% of the global population, including both adults and children. Therefore, it is of interest to report the molecular docking analysis of tyrosinase (PDB: 1WX3) with compounds from poly-herbal formulation for vitiligo treatment. Analysis shows that the lead bioactive compounds exhibit binding energies ranging from -3.10 Kcal/mol to -7.36 Kcal/mol having 2-6 hydrogen bond interactions with key amino acid residues in the target protein. Beta-sitosterol showed the highest binding affinity (-7.36 Kcal/mol), followed by Orientin (-7.06 Kcal/mol) and other compounds such as masilinic acid, luteolin, glycyrrhizin, corilagin, gallic acid, boeravinone B and trigonelline. Thus, the phytochemicals in the poly-herbal formulation enhance the activity of the tyrosinase enzyme, supporting melanogenesis, making it a potential treatment for vitiligo.
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