Biotin-Initiated Poly(oxazoline)s.

Joseph A Garcia, Ashley Vergara Mendez, Ellen M Sletten

Abstract read

In one paragraph

Article in Macromolecules, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Acid-cleavable poly(oxazoline) surfactants.Polymer chemistry · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Joseph A GarciaDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095, United States.ORCID 0000-0002-0253-3121

Ashley Vergara MendezDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095, United States.

Ellen M SlettenDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095, United States.ORCID 0000-0002-0049-7278

Funding

Robust microdroplet-based mechanical probes for wide-ranging mechanobiology applicationsR01GM135380 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CAMPAS, OTGER, SLETTEN, ELLEN MAY · 2019 to 2022

$1.8M

NIGMS NIH HHS R01 GM135380

6 · The paper itself

Abstract

Biotinylated hydrophilic polymers are used in a plethora of chemical and biochemical assays due to the exceptional affinity of biotin for (strept)avidin. Here, we report a facile method for the installation of biotin at the end of poly(oxazoline)s (P(Ox)) using an electrophilic biotin initiator. While this method is applicable to many different oxazoline monomers, we focus on biotin-poly(2-methyl-2-oxazoline) as it is a desirable alternative to poly(ethylene glycol) (PEG), which has rising immunogenicity concerns. A further advantage of P(Ox) over PEG is the high degree of chemical flexibility that can be imparted, which we showcase through the preparation of varied molecular weight, amphiphilic, and bifunctional P(Ox)s. Furthermore, we demonstrate the high efficacy of these biotin polymers through a series of common biochemical assays that frequently utilize the biotin-streptavidin pair.

Identifiers

PMID40599896

DOI10.1021/acs.macromol.4c00324

PMCPMC12208678

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.