ArticleAesthetic surgery journal. Open forum2025
Dose-Dependent Effects of Cross-Linked Hyaluronic Acid Through Intradermal Injection on Female Facial Photoaging: A Prospective Study.
Article in Aesthetic surgery journal. Open forum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Efficacy and Safety of a Novel Sodium Hyaluronate Composite Solution via Mesotherapy for Facial Rejuvenation: A Multicenter Randomized Controlled Study.Plastic and reconstructive surgery. Global open · 2026Article
- The Tripartite Regulatory Framework of the Skin Extracellular Microenvironment and Related Anti-aging Strategies.Mini reviews in medicinal chemistry · 2026Review
- Branched Hyaluronic Acid for Reduced Viscosity and Enhanced Moisturization.Materials (Basel, Switzerland) · 2025Article
- Advances in the treatment of acne scars.Frontiers in medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Skin photoaging significantly affects skin health and aesthetics, with undesirable appearances negatively impact individual psychological well-being. Intradermal injection of cross-linked hyaluronic acid (HA) has been successfully utilized to improve facial skin photoaging. However, the correlations between the number of treatments and therapeutic efficacy, as well as the dosage and therapeutic outcomes of intradermal injections of cross-linked HA, remain underexplored. Objectives: The authors observe the effects of intradermal injection of cross-linked HA in different doses and frequencies on improving facial skin photoaging. Methods: A randomized, split-face design with participant blinding, self-controlled, prospective clinical study was conducted to evaluate the efficacy of different dosages of intradermal injections of cross-linked HA in improving mild-to-moderate female facial photoaging. Results: Cross-linked HA significantly improved facial photoaging scores, reduced transepidermal water loss, enhanced skin elasticity, and increased patients' satisfaction. The effects were cumulative following sequential treatments, with the high-dosage group demonstrating superior efficacy and longer lasting outcomes compared with the low-dosage group. Conclusions: High-dosage, multisession intradermal injection protocols of cross-linked HA offer more effective improvements in the manifestations of facial photoaging, with superior efficacy and longer lasting outcomes. Level of Evidence 2 Therapeutic:
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.