SynthesisFrontiers in neuroimaging2025
The use of intraoperative tractography in brain tumor and epilepsy surgery: a systematic review and meta-analysis.
Synthesis in Frontiers in neuroimaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neuronavigation-guided precise resection versus conventional glioma surgery: a meta-analysis of clinical outcomes.Frontiers in neurology · 2026Pooled it
- BBB-Permeable Near-Infrared Oxazine Fluorophores for White Matter Tract Imaging.bioRxiv : the preprint server for biology · 2026Article
- Structural Fiber Tract Alterations in Relation to Surgery in Children With a Posterior Fossa Tumor.NMR in biomedicine · 2026Article
- What needs to be standardized for reliable, reproducible, and robust tractography?GigaScience · 2026Review
- Multimodal Imaging in Epilepsy Surgery for Personalized Neurosurgical Planning.Journal of personalized medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Tractography is the only available technique for visualizing whitematter pathways within the living brain. Avoiding these pathways during surgical interventions for brain tumors and epilepsy is key to reducing postoperative neurological deficits whilst achieving maximum safe resection. Despite this, the use of intraoperative tractography is not widely adopted in clinical practice, with time required to run analyses often cited as a limitation. This systematic review and meta-analysis aimed to assess the impact of intraoperative tractography on neurosurgical outcomes in both tumor and epilepsy surgeries. Methods: Conducted in accordance with PRISMA guidelines, five major databases were searched using neurosurgery, tractography, brain tumor, and epilepsy terms. Original primary research studies in English were included. A risk of bias analysis was conducted using the MINORS tool. Results: The search strategy identified 2,611 papers. Following de-duplication and screening, 26 papers were included in the final analysis. Risk of bias was found to be moderate. Findings suggest that the use of intraoperative tractography has the potential to improve surgical outcomes for patients undergoing tumor and epilepsy surgery. Meta-analysis indicated a good rate of gross total resection, 79%, and only three studies of brain tumors and one study of epilepsy reported worsening of neurological deficits. Discussion: Though the evidence supporting its use remains limited, results indicate that intraoperative tractography can be a valuable tool in improving neurosurgical outcomes and reducing the risk of postoperative deficits. Further research is required to determine optimal use in clinical practice. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42023427427, Identifier: CRD42023427427.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.