Evidence map›Paper›PMID 40599655›Full record

ArticleCytotechnology2025

Research on the mechanism of GRIM-19 affecting lung adenocarcinoma through regulating MDM2 and EMT pathways.

Pengfei Guo, Song Zhao, Xiaoli Han, Jingtao Huang, Zongying Liang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cytotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Pengfei GuoDepartment of Thoracic Surgery, Affiliated Hospital of Chengde Medical University, Chengde, China.
Song ZhaoDepartment of Thoracic Surgery, Affiliated Hospital of Chengde Medical University, Chengde, China.
Xiaoli HanDepartment of Thoracic Surgery, Affiliated Hospital of Chengde Medical University, Chengde, China.
Jingtao HuangDepartment of Thoracic Surgery, Affiliated Hospital of Chengde Medical University, Chengde, China.
Zongying LiangDepartment of Thoracic Surgery, Affiliated Hospital of Chengde Medical University, Chengde, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previously, there have been reports of decreased expression of GRIM-19 and increased expression of MDM2 in lung adenocarcinoma. However, the relationship between GRIM-19 and MDM2 in lung adenocarcinoma has not been reported yet. In this study, we demonstrated that GRIM-19mRNA expression was reduced in lung adenocarcinoma tissue while MDM2mRNA expression was increased. Pearson correlation coefficient analysis showed a significant correlation between GRIM-19mRNA and MDM2mRNA (r = -0.970, Supplementary Information: The online version contains supplementary material available at 10.1007/s10616-025-00797-5.

Indexed as

Adenocarcinoma of the lungEMTGRIM-19MDM2

Identifiers

PMID40599655
PMCPMC12206682

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.