Evidence map›Paper›PMID 40599649›Full record

ArticleFrontiers in cellular and infection microbiology2025

Treatment of bacterial biothreat agents with a novel purified bioactive lactoferrin affects both growth and biofilm formation.

Christian Xander, Elsie E Martinez, Ronald G Toothman, Christina L Gardner, Ju Qiu, Jonathan Snedeker, Matthew H Bender, Christopher Hlubb, Crystal W Burke, Joel A Bozue and 1 more

Abstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Animal modelling with theMicrobiology (Reading, England) · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Christian Xander *Bacteriology Division, United States (U.S.) Army Medical Research Institute of Infectious Diseases (USAMRIID), Frederick, MD, United States.
Elsie E Martinez *Bacteriology Division, United States (U.S.) Army Medical Research Institute of Infectious Diseases (USAMRIID), Frederick, MD, United States.
Ronald G ToothmanBacteriology Division, United States (U.S.) Army Medical Research Institute of Infectious Diseases (USAMRIID), Frederick, MD, United States.
Christina L GardnerVirology Division, United States (U.S.) Army Medical Research Institute of Infectious Diseases (USAMRIID), Frederick, MD, United States.
Ju QiuRegulated Research Administration Division, United States (U.S.) Army Medical Research Institute of Infectious Diseases (USAMRIID), Frederick, MD, United States.
Jonathan SnedekerLactea Therapeutics, Frederick, MD, United States.
Matthew H BenderLactea Therapeutics, Frederick, MD, United States.
Christopher HlubbLactea Therapeutics, Frederick, MD, United States.
Crystal W BurkeVirology Division, United States (U.S.) Army Medical Research Institute of Infectious Diseases (USAMRIID), Frederick, MD, United States.
Joel A BozueBacteriology Division, United States (U.S.) Army Medical Research Institute of Infectious Diseases (USAMRIID), Frederick, MD, United States.
Kevin D MlynekBacteriology Division, United States (U.S.) Army Medical Research Institute of Infectious Diseases (USAMRIID), Frederick, MD, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lactoferrin is known to exhibit broad spectrum activity against a multitude of bacteria, fungi, and viruses due to its multi-functional mode of action. Recently, Lactea Therapeutics and its affiliates have developed a novel, patent-pending technology to purify naturally derived bovine lactoferrin (Lactea Lf) for use as a medical countermeasure that was not previously available. To assess the efficacy of Lactea Lf against biothreat pathogens, we performed biofilm inhibition assays and generated dose-response curves against

Indexed as

Anti-Bacterial AgentsBiofilmsBiological Warfare AgentsBurkholderiaLactoferrinAnimalsBurkholderia pseudomalleiCattleDisease Models, AnimalFemaleFrancisella tularensisMiceMicrobial Sensitivity TestsAnti-Bacterial AgentsBiological Warfare AgentsLactoferrinbiofilmBurkholderiaFrancisellaglanderslactoferrinmelioidosistularemia

Identifiers

PMID40599649
PMCPMC12209266

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.