Evidence map›Paper›PMID 40599586›Full record

ArticleRSC medicinal chemistry2025

Structure-activity relationships of 1,5-dihydro-2

Michael G Thomas, Joanne Dunne, Peter G Dodd, Emiliana D'Oria, Laura Frame, Adolfo Garcia-Perez, Kate McGonagle, Pilar Manzano, Lorna MacLean, Christy Paterson and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Michael G ThomasDrug Discovery Unit, University of Dundee Dundee UK M.Z.Thomas@dundee.ac.uk p.g.dodd@dundee.ac.uk.ORCID https://orcid.org/0000-0003-0377-0281
Joanne DunneDrug Discovery Unit, University of Dundee Dundee UK M.Z.Thomas@dundee.ac.uk p.g.dodd@dundee.ac.uk.
Peter G DoddDrug Discovery Unit, University of Dundee Dundee UK M.Z.Thomas@dundee.ac.uk p.g.dodd@dundee.ac.uk.
Emiliana D'OriaTres Cantos Medicines Development Campus, DDW and CIB, GlaxoSmithKline Tres Cantos Spain.
Laura FrameDrug Discovery Unit, University of Dundee Dundee UK M.Z.Thomas@dundee.ac.uk p.g.dodd@dundee.ac.uk.
Adolfo Garcia-PerezTres Cantos Medicines Development Campus, DDW and CIB, GlaxoSmithKline Tres Cantos Spain.
Kate McGonagleDrug Discovery Unit, University of Dundee Dundee UK M.Z.Thomas@dundee.ac.uk p.g.dodd@dundee.ac.uk.
Pilar ManzanoTres Cantos Medicines Development Campus, DDW and CIB, GlaxoSmithKline Tres Cantos Spain.
Lorna MacLeanDrug Discovery Unit, University of Dundee Dundee UK M.Z.Thomas@dundee.ac.uk p.g.dodd@dundee.ac.uk.
Christy PatersonDrug Discovery Unit, University of Dundee Dundee UK M.Z.Thomas@dundee.ac.uk p.g.dodd@dundee.ac.uk.
Jennifer RileyDrug Discovery Unit, University of Dundee Dundee UK M.Z.Thomas@dundee.ac.uk p.g.dodd@dundee.ac.uk.
John ThomasDrug Discovery Unit, University of Dundee Dundee UK M.Z.Thomas@dundee.ac.uk p.g.dodd@dundee.ac.uk.
Leah S TorrieDrug Discovery Unit, University of Dundee Dundee UK M.Z.Thomas@dundee.ac.uk p.g.dodd@dundee.ac.uk.
Karolina WrobelDrug Discovery Unit, University of Dundee Dundee UK M.Z.Thomas@dundee.ac.uk p.g.dodd@dundee.ac.uk.
Kevin D ReadDrug Discovery Unit, University of Dundee Dundee UK M.Z.Thomas@dundee.ac.uk p.g.dodd@dundee.ac.uk.
Maria MarcoTres Cantos Medicines Development Campus, DDW and CIB, GlaxoSmithKline Tres Cantos Spain.ORCID https://orcid.org/0000-0002-2442-0021
Manu De RyckerDrug Discovery Unit, University of Dundee Dundee UK M.Z.Thomas@dundee.ac.uk p.g.dodd@dundee.ac.uk.ORCID https://orcid.org/0000-0002-3171-3519

Funding

Wellcome Trust 203134Wellcome Trust 224024
6 · The paper itself

Abstract

Chagas disease, caused by infection with the protozoan parasite

Identifiers

PMID40599586
PMCPMC12208134

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.