ArticleCureus2025
Comparative Evaluation of Tissue Attenuation Imaging (TAI) and Ultrasound Attenuation Parameter (UAP) for Noninvasive Quantification and Grading of Hepatic Steatosis.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND AND
aimHepatic steatosis is a major component of chronic liver disease and a key predictor of disease progression. The ultrasound attenuation parameter (UAP) is widely used via transient elastography (TE) for quantifying hepatic fat, but limited access and cost restrict its utility in routine practice. This study aimed to evaluate the correlation between tissue attenuation imaging (TAI) and UAP and to propose reference ranges for grading hepatic steatosis (S0-S3) using TAI as a noninvasive alternative.
methodsThis prospective observational study was conducted at Mann Scanning Centre, Jalandhar, Punjab, India. A total of 120 adult patients undergoing liver evaluation were included. All subjects underwent TE with UAP measurement and ultrasound-based TAI. Steatosis grading (S0-S3) was assigned based on UAP thresholds. Correlation between TAI and UAP was assessed using Spearman's and Pearson's coefficients. Receiver operating characteristic (ROC) curve analysis was performed to derive optimal TAI cutoffs corresponding to each steatosis grade.
resultsTAI showed a strong positive correlation with UAP (Spearman's ρ = 0.61, p < 0.001). TAI values increased progressively across steatosis grades S0 to S3. ROC analysis demonstrated an area under the curve (AUC) of 0.84 for detecting moderate-to-severe steatosis (≥ S2) using TAI. Proposed TAI thresholds for steatosis grading were: S0 (< 0.70 dB/cm/MHz), S1 (0.70-0.79 dB/cm/MHz), S2 (0.80-0.89 dB/cm/MHz), and S3 (≥ 0.90 dB/cm/MHz). The agreement between TAI-based and UAP-based grading was substantial (κ = 0.78).
conclusionsTissue attenuation imaging is a reliable and accessible ultrasound-based technique for quantifying hepatic steatosis. It correlates well with UAP and can serve as a practical alternative for steatosis grading in settings where TE is unavailable.
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