Trial reportOpen forum infectious diseases2025
Effect of a Widespread Reduction in Treatment Duration for Group A Streptococcal Pharyngitis on Outcomes Including Household Transmission.
Trial report in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Shorter-course treatment for group A streptococcal (GAS) pharyngitis may be equivalent to 10 days for clinical cure but effectiveness for pharyngeal GAS eradication is uncertain. The effect on household transmission has not been examined directly. In 2022, a laboratory antimicrobial stewardship initiative drove an abrupt reduction in treatment durations for GAS pharyngitis locally. This study aimed to assess whether this had any negative effect on key treatment outcomes: clinical failure, microbiological failure, immune sequelae, and household GAS transmission. Methods: Positive throat swab cultures for GAS 2 years prechange until 25 months postchange were matched to antibiotic dispensing data. Logistic models were fitted to examine associations between treatment duration and 30-day repeat antibiotic treatment, repeat GAS-positive throat swab cultures, hospitalization, incident household cases, and 90-day incidence of rheumatic fever. Results: A total of 851 patients prechange and 1746 postchange were included; 31.3% prechange received ≤7 days' treatment versus 59.0% postchange ( Conclusions: Shorter-course treatment had no detectable negative effect on GAS pharyngitis outcomes in this population, including patients receiving no antibiotics. Short-course therapy for GAS pharyngitis has been associated with lower pharyngeal eradication; this did not translate to a detectable increase in household transmission in this real-world setting, which to our knowledge is a novel finding.
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