ArticleOpen forum infectious diseases2025
Oxidative Stress Induced Liver Damage in Dengue Is Exacerbated in Those With Obesity.
Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Early individualized risk prediction using clinical data for children during the febrile phase of dengue in outpatient settings in Vietnam and Thailand.PLOS digital health · 2026Article
- Remodelled cholesteryl ester enriched lipid droplets fuel flavivirus morphogenesis.bioRxiv : the preprint server for biology · 2025Article
- Functionality and phenotype of T cells in patients with varying severity of acute dengue and metabolic status.medRxiv : the preprint server for health sciences · 2025Article
Corrections and comments
- Update of
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: As there are limited data on the association of obesity with liver dysfunction and oxidative stress in patients with acute Dengue, we investigated liver dysfunction associated with obesity, oxidative stress, and inflammatory markers in a large cohort of patients with varying severity of illness. Methods: Five hundred seventy-seven adults with a duration of illness ≤4 days at time of admission were followed up from admission to discharge. Aspartate transaminase (AST), alanine transaminase (ALT), C-reactive protein, ferritin, 4-hydroxynonenal (4-HNE), and malondialdehyde (MDA) levels were measured, along with the height, weight, and waist circumference. Results: AST, ALT, CRP, and ferritin levels were significantly higher in patients with central obesity (waist circumference of ≥80 cm in women or ≥90 cm in men) compared with leaner individuals. ALT and CRP levels were also significantly higher in patients with a body mass index (BMI) of ≥23.9 kg/m Conclusions: 4-HNE and MDA appear to play different roles in the pathogenesis of Dengue, which should be further investigated for identification of therapeutic targets for treatment of Dengue.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.