ArticleArchives of Razi Institute2024
Inflamatory Markers in Cows Affected by Subclinical Mastitis Due To
Article in Archives of Razi Institute, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The investigation of serum amyloid A (SAA), IL-6, and IL-8 concentrations in serum during episodes of clinical and subclinical mastitis is of significant value. The objective of this study was to assess the diagnostic value of Serum Amyloid A (SAA), IL-6, and IL-8 in the early detection of subclinical mastitis in cows infected with Escherichia coli (E. coli) and staphylococcus infections. This cross-sectional analytical study, conducted in 2023 at the Veterinary Laboratory in Urmia, Iran, evaluated inflammatory markers in 79 dairy cows with clinical and subclinical mastitis. The cows were divided into three groups: healthy cows, cows with subclinical mastitis, and cows with clinical mastitis. Each of these groups was then evaluated for Serum Amyloid A (SAA), IL-6, and IL-8. The diagnostic value of the inflammatory markers was determined by calculating the areas under the curves (AUCs) of the receiver operating characteristic (ROC) curves. In general, among patients with a positive culture test result (57%), 19% were found to be infected with E. coli, 22.8% with Streptococcus uberis, and 15.2% (12 cases) with Staphylococcus aureus. A strong correlation was observed between the mean SCC and the values of IL-6 (P<0.005), IL-8 (P<0.005), and SAA (P<0.005). Furthermore, a strong correlation was observed between SAA and IL-8 (P<0.005). The value of IL-6 exhibited a moderate correlation with both IL-8 (P<0.005) and SAA (P<0.005). The sensitivity and specificity of SCC (0.98), SAA (0.90), IL-6 (0.95), and IL-8 (0.87) were high for the diagnosis of mastitis in cows. The present study demonstrated that mastitis in dairy cows is associated with an increase in inflammatory cytokines, including amyloid A, IL-6, and IL-8. The findings of this study indicate that fluctuations in these biomarkers may serve as a potential indicator for disease diagnosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.