Evidence map›Paper›PMID 40599394›Full record

ReviewInternational journal of nanomedicine2025

Tailored Extracellular Vesicles from Dental Stem Cells: Advances in Specific Modifications for Enhanced Therapeutic Applications.

Xiaojing Liu, Ziwei Li, Jiao Fu, RuoXuan Wang, Jihui He, Juming Yao, Qingsong Ye, Yan He

Abstract readReview
In one paragraph

Review in International journal of nanomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaojing LiuFirst Clinical College, Wuhan University of Science and Technology, Wuhan, Hubei, People's Republic of China.ORCID 0009-0008-8887-2298
Ziwei LiCenter of Regenerative Medicine, Renmin Hospital of Wuhan University, Wuhan, Hubei, People's Republic of China.
Jiao FuFirst Clinical College, Wuhan University of Science and Technology, Wuhan, Hubei, People's Republic of China.
RuoXuan WangFirst Clinical College, Wuhan University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Jihui HeFirst Clinical College, Wuhan University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Juming YaoFirst Clinical College, Wuhan University of Science and Technology, Wuhan, Hubei, People's Republic of China.
Qingsong YeCenter of Regenerative Medicine, Renmin Hospital of Wuhan University, Wuhan, Hubei, People's Republic of China.
Yan HeFirst Clinical College, Wuhan University of Science and Technology, Wuhan, Hubei, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles(EVs) derived from dental stem cells have emerged as a key focus in regenerative medicine, owing to their remarkable ability to promote tissue repair and regeneration. Recent advancements revealed that targeted modifications can significantly boost their functional properties, creating new possibilities for the regeneration field. This article provides an overview of the most recent progress in EVs derived from dental stem cells research, with a particular emphasis on diverse engineering strategies such as genetic, chemical, and physical techniques, and their role in enhancing therapeutic performance. Furthermore, the influence of these engineering methods on the yield of EVs is thoroughly examined, offering critical perspectives for improving large-scale manufacturing efficiency. Pretreatment-generated conditioned dental stem cells-derived EVs are also explored as an innovative approach, demonstrating superior biological functions and regenerative potential. By integrating contemporary findings, this review underscores the superior capabilities of modified EVs derived from dental stem cells in driving progress in regenerative medicine and lays the groundwork for future investigations focused on clinical applications and therapeutic innovation.

Indexed as

Dental PulpExtracellular VesiclesRegenerative MedicineStem CellsAnimalsHumansTissue Engineeringextracellular vesicleshypoxiainflammationpreconditioningpredifferentiationregeneration

Identifiers

PMID40599394
PMCPMC12209602

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.