ArticleBioactive materials2025
Extracellular vesicles derived from salivary gland stem cells cultured on microwell scaffolds loaded with WNT3A promote the recovery of salivary gland function damaged by radiation via the YWHAZ-PI3K-AKT pathway.
Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- 4-Octyl Itaconate Attenuates Age-Induced Parotid Gland Dysfunction Through the Suppression of Fibrosis and Lipid Deposition by AMPKα/PPARα and the Inhibition of Oxidative Stress via the AMPKα/Nrf2 Signaling Pathway.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- The synergistic applications of organoids and exosomes in disease modeling and disease treatment.Molecular biology reports · 2026Review
- Functional human salivary gland organoids for tissue regeneration in chemically defined culture systems.Cell reports. Medicine · 2026Article
- Tissue regeneration strategies based on mesenchymal stem cell-derived extracellular vesicles: from bench to bedside.Burns & trauma · 2026Review
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Authors and funding
13 authors.
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Abstract
Salivary gland (SG) stem cell-derived extracellular vesicles (EVs) are promising agents for regenerative therapy, but efficient production and targeted delivery remain key challenges. We developed a WNT3A-releasing double-layered microwell scaffold by integrating WNT3A-loaded poly(D,L-lactide-co-glycolide) (PLGA) nanofibers with a polycaprolactone (PCL)-based microwell array. This 3D platform promotes salivary gland epithelial stem cell (sgEpSC) spheroid formation and sustained biochemical stimulation. EVs derived from four culture conditions (2D dish, 3D Microwell, 3D PLGA-Microwell, and 3D WNT-Microwell) were analyzed for yield, purity, and therapeutic efficacy. The WNT-Microwell system enabled stable spheroid formation and sustained WNT3A release over 7 days. sgEpSCs cultured on this platform produced significantly higher EV yields than other conditions. In a murine model of radiation-induced SG damage, retroductal injection of EVs from 3D spheroids cultured in WNT3A-releasing microwells (3D
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