Evidence map›Paper›PMID 40599341›Full record

ArticleBioactive materials2025

Novel strategy for tumor immunotherapy using FITC-folate bispecific adapter bridged CAR immune cell cocktails.

Bin Liu, Jingqiao Shen, Yunhan Wu, Chun Fai Wong, Tran Yin Hei, Johnny Wen-Tao Li, Sydney N Hummel, Gyuhyung Jin, Nathan R Petrucci, Dan Michelle Wang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Bin LiuDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, 999077, Hong Kong, China.
Jingqiao ShenDavidson School of Chemical Engineering, Purdue University, West Lafayette, IN, 47907, USA.
Yunhan WuDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, 999077, Hong Kong, China.
Chun Fai WongDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, 999077, Hong Kong, China.
Tran Yin HeiDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, 999077, Hong Kong, China.
Johnny Wen-Tao LiDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, 999077, Hong Kong, China.
Sydney N HummelDavidson School of Chemical Engineering, Purdue University, West Lafayette, IN, 47907, USA.
Gyuhyung JinDavidson School of Chemical Engineering, Purdue University, West Lafayette, IN, 47907, USA.
Nathan R PetrucciDavidson School of Chemical Engineering, Purdue University, West Lafayette, IN, 47907, USA.
Dan Michelle WangSchool of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, 999077, Hong Kong, China.
Xiaoping BaoDavidson School of Chemical Engineering, Purdue University, West Lafayette, IN, 47907, USA.
Cheng DongDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, 999077, Hong Kong, China.
Yun ChangDepartment of Biomedical Engineering, The Hong Kong Polytechnic University, 999077, Hong Kong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adoptive immune cell-based therapies have shown promise in cancer treatment, yet their efficacy against solid tumors is often limited by the immunosuppressive tumor microenvironment (TME). To overcome these barriers, we design an innovative immune cell cocktail as a combinatorial biomaterial platform, which harnessing the complementary functions of neutrophils and natural killer (NK) cells derived from human pluripotent stem cells (hPSCs). Using CRISPR/Cas9, we introduce an anti-fluorescein isothiocyanate (FITC) chimeric antigen receptor (CAR) construct into the AAVS1 safe harbor locus of hPSCs, allowing for the differentiation of CAR-modified neutrophils and NK cells. These CAR neutrophils exhibit robust anti-tumor activity, forming immune synapses with tumor cells tagged

Indexed as

Bispecific adapterCocktail biomaterialHuman pluripotent stem cellsNatural killer cellsNeutrophils

Identifiers

PMID40599341
PMCPMC12212159

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.