ArticleSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2025
[Relationship Between Different Traditional Chinese Medicine Syndrome Types and Gut Microbiota in Patients With Type 2 Diabetes Mellitus].
Article in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To observe the characteristics of gut microbiota in patients with type 2 diabetes mellitus (T2DM) with different traditional Chinese medicine (TCM) syndrome types, and to further explore the key microbial communities and functional differences affecting syndrome differentiation. Methods: A total of 45 patients who visited the Department of Geriatrics, Hunan Provincial Hospital of Integrated Traditional Chinese and Western Medicine in 2023 were enrolled. These included 15 T2DM patients with qi-yin deficiency and blood stasis syndrome (Group A), 15 T2DM patients with qi-yin deficiency syndrome (Group B), and 15 non-diabetic patients from the same period (Group C). Fecal samples were collected, and 16S rRNA sequencing and analysis were performed. Results: 1) A total of 1564 operational taxonomic units (OTUs) were obtained from the three groups of patients, with 224, 127, and 351 unique OTUs identified in Groups A, B and C, respectively. 2) Both α- and β-diversity analyses indicated differences among the gut microbiota of the three groups. For instance, in the α-diversity analysis, the Sobs index showed significant inter-group differences ( Conclusion: The differences in the gut microbiota characteristics and functions among patients with specific TCM syndromes of T2DM may provide references for TCM syndrome differentiation and therapeutic mechanisms.
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