Evidence map›Paper›PMID 40599287›Full record

ArticleSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2025

[Biological Aging Affects the Rate of Cognitive Decline in Middle-aged and Elderly Populations: A Cohort Study Based on CHARLS].

Huiyu He, Mengling Wei, Jiao Zhong, Juan Wang, Lei Huang, Yajia Lan, Yang Zhang

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Huiyu He/ （ 610041） Department of Environmental and Occupational Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.
Mengling Wei/ （ 610041） Department of Environmental and Occupational Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.
Jiao Zhong/ （ 610041） Department of Environmental and Occupational Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.
Juan Wang/ （ 610041） Department of Environmental and Occupational Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.
Lei Huang/ （ 610041） Department of Environmental and Occupational Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.
Yajia Lan/ （ 610041） Department of Environmental and Occupational Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.
Yang Zhang/ （ 610041） Department of Environmental and Occupational Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate the relationship between biological aging and the rate of cognitive decline in middle-aged and elderly populations. Methods: Longitudinal tracking data of cognitive function were obtained from the China Health and Retirement Longitudinal Study (CHARLS). We employed the Klemera and Doubal method (KDM) to estimate biological age (BA), and calculate the biological aging index (BAI) and biological aging type (BAT). A multivariate linear regression model was employed to analyze the relationships between baseline BAI, BAT, and cognitive function scores. Based on the baseline analysis, a mixed-effects model was used to examine the longitudinal associations between baseline BAI, BAT, and cognitive function during follow-up. Results: A total of 5897 participants were included in the study. BAI was found to be negatively associated with baseline cognitive function scores, with the partial regression coefficient ( Conclusion: Biological aging affects the rate of cognitive decline in middle-aged and elderly populations. A higher BAI is associated with a faster decline in cognitive function. Compared with those with lagged aging, individuals with premature aging exhibit a more rapid rate of cognitive decline.

Indexed as

AgingCognitionCognitive DysfunctionAgedChinaCohort StudiesFemaleHumansLongitudinal StudiesMaleMiddle AgedAgingBiological ageCognitive function

Identifiers

PMID40599287
PMCPMC12207056

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.