Evidence map›Paper›PMID 40599285›Full record

ArticleSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2025

[Neuroprotective Effects of Anisodine Hydromide in a Rat Model of Vascular Dementia and the Antioxidative Stress Mechanisms Involved].

Yixue Qin, Yan Qiu, Jian Zhong, Zhi Ouyang, Linlu Jin, Hailin Wu, Ye Zeng

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Unraveling the Effects ofInternational journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yixue Qin（ 610041） Institute of Biomedical Engineering, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.
Yan Qiu（ 610041） Institute of Biomedical Engineering, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.
Jian Zhong（ 610041） Institute of Biomedical Engineering, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.
Zhi Ouyang（ 610041） Institute of Biomedical Engineering, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.
Linlu Jin（ 610041） Institute of Biomedical Engineering, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.
Hailin Wu（ 610041） Institute of Biomedical Engineering, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.
Ye Zeng（ 610041） Institute of Biomedical Engineering, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Vascular dementia (VD) is a common cognitive dysfunction associated with cerebrovascular disease. This study is aimed at investigating the therapeutic effect of anisodine hydromide (AH) on VD and the potential antioxidative stress mechanisms involved. Methods: A VD model was established in Sprague-Dawley (SD) rats through permanent bilateral common carotid artery occlusion. The rats were divided into a sham group, a VD model group, and AH treatment groups receiving AH at low, medium, or high doses ( Results: Compared with the sham group, the nerve function and limb coordination of rats in the VD model group were significantly impaired ( Conclusion: AH modulates SOD and MDA levels and reduces oxidative stress injury, thereby improving neurological function and limb coordination and showing potential therapeutic effects in VD. The neuroprotective effects of AH may be related to its antioxidative stress and antiapoptotic mechanisms, and the M2 receptor may be a potential target of its actions. These findings provide an important theoretical basis for the development of new therapeutic strategies for VD.

Indexed as

Dementia, VascularNeuroprotective AgentsOxidative StressAnimalsAntioxidantsApoptosisDisease Models, AnimalMaleMalondialdehydeRatsRats, Sprague-DawleyReactive Oxygen SpeciesSuperoxide DismutaseAntioxidantsMalondialdehydeNeuroprotective AgentsReactive Oxygen SpeciesSuperoxide DismutaseAnisodineMalondialdehydeM receptorOxidative stressSuperoxide dismutaseVascular dementia

Identifiers

PMID40599285
PMCPMC12207047

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.