Evidence map›Paper›PMID 40599271›Full record

ArticleSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2025

[Mechanisms of Neiyiting Decoction in Preventing Postoperative Recurrence of Endometriosis by Inhibiting Macrophage M1 Polarization Through the TREM1/TLR4/NF-κB Signaling Pathway].

Lijuan Lu, Weiwei Zeng, Jingwen Wang, Lurong Zhang, Ying Liu, Xueliang Sun, Wen Xu, Xiaohui Fang, Yichao Yan, Qinhua Xia

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. [Risk Factors for Recurrence and Their Predictive Value in Endometriosis Patients After Laparoscopic Surgery].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lijuan Lu（ 215007） Department of Gynecology, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou 215007, China.
Weiwei Zeng（ 215007） Department of Gynecology, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou 215007, China.
Jingwen Wang（ 215007） Department of Gynecology, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou 215007, China.
Lurong Zhang（ 215007） Department of Gynecology, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou 215007, China.
Ying Liu（ 215007） Department of Gynecology, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou 215007, China.
Xueliang Sun（ 215007） Department of Gynecology, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou 215007, China.
Wen Xu（ 215007） Department of Gynecology, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou 215007, China.
Xiaohui Fang（ 215007） Department of Gynecology, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou 215007, China.
Yichao Yan（ 215007） Department of Gynecology, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou 215007, China.
Qinhua Xia（ 215007） Department of Gynecology, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou 215007, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The high post-surgery recurrence rate of endometriosis (EMs) has emerged as a challenge in the long-term manaagement of the condition. This study is aimed at investigating the mechanisms of Neiyiting (NYT) decoction in preventing postoperative recurrence of EMs. Methods: An animal model of EMs postoperative recurrence and a model of endometrial stromal cells (hEM15A) cocultured with macrophages (RAW 264.7 cell line) were established for both Results: Compared with the Model group, the volume of recurrent lesions in the NYT-H group was reduced ( Conclusion: NYT decoction can inhibit macrophage M1 polarization through the TREM1/TLR4/NF-κB signaling pathway, improve the inflammation level, and inhibit the formation of ectopic endometrial lesions, thereby preventing postoperative recurrence of EMs.

Indexed as

Drugs, Chinese HerbalEndometriosisMacrophagesNF-kappa BSignal TransductionToll-Like Receptor 4AnimalsDisease Models, AnimalFemaleHumansMiceRatsRats, Sprague-DawleyRAW 264.7 CellsRecurrenceTriggering Receptor Expressed on Myeloid Cells-1Drugs, Chinese HerbalNF-kappa BToll-Like Receptor 4Triggering Receptor Expressed on Myeloid Cells-1EndometriosisMacrophagesRecurrence

Identifiers

PMID40599271
PMCPMC12207022

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.