ReviewComputational and structural biotechnology journal2025
Computational modeling of cotranscriptional RNA folding.
Review in Computational and structural biotechnology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- When does molecular dynamics improve RNA models? Insights from CASP15 and practical guidelines.Computational and structural biotechnology journal · 2025Article
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2 authors.
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Abstract
An RNA folds as it is transcribed. RNA folding during transcription differs fundamentally from thermodynamic folding. While thermodynamic folding reaches an equilibrium ensemble of structures, cotranscriptional folding is a kinetic process where the RNA structure evolves as the chain elongates during transcription. This dynamic folding pathway causes cotranscriptional structures often to deviate from thermodynamic predictions, as the system rarely reaches equilibrium. Since these cotranscriptional effects can persist in the mature RNA's structure, understanding this kinetic process is crucial. While experimental studies of cotranscriptional folding have been successful, they remain resource-intensive. Computational modeling has emerged as an increasingly practical and powerful approach for investigating these dynamics. This short review examines current computational methods and tools for simulating cotranscriptional folding, with the goal of advancing our understanding of RNA folding mechanisms.
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Registered trials
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