Evidence map›Paper›PMID 40599222›Full record

ArticleInternational journal of population data science2025

Development and validation of a mortality risk prediction index score for adults living with HIV and multiple chronic comorbidities.

Viviane D Lima, Bronhilda T Takeh, Neil Faught, Hasan Nathani, Jielin Zhu, Scott Emerson, Katerina Dolguikh, Jason Trigg, Kate A Salters, Rolando Barrios and 1 more

Abstract readValidation Study
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Article in International journal of population data science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

11 authors.

Viviane D LimaBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
Bronhilda T TakehBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
Neil FaughtBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
Hasan NathaniBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
Jielin ZhuBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
Scott EmersonBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
Katerina DolguikhBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
Jason TriggBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
Kate A SaltersBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
Rolando BarriosBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
Julio S G MontanerBritish Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Aging while living with HIV poses new challenges in clinical management, mainly due to the onset of multiple chronic comorbidities. Population-specific risk prediction indices considering comorbidities and other risk factors are essential to comprehensively characterise disease burden among PLWH. We developed and validated a mortality risk prediction index (MRP Methods: Participants were ≥18 years and had initiated antiretroviral therapy (ART) between 01/2001 and 12/2018, in British Columbia, Canada. The index date was randomly selected between one-year post-ART initiation and the end of the follow-up. Participants were followed for at least one year from the index date until 12/2019, the last contact date, or the date of death (all-cause), whichever came first. The MRP Results: The final model demonstrated the highest discrimination (c-statistic 0.8355, 95% CI: 0.8187-0.8523 in the training dataset and 0.7965, 95% CI: 0.7664-0.8266 in the test dataset). The comorbidities with the highest weights in the MRP Conclusions: The MRP

Indexed as

HIV InfectionsAdultAgedBritish ColumbiaComorbidityFemaleHumansMaleMiddle AgedRisk AssessmentRisk Factorsagingburden of diseasecomorbiditymortalitymortality risk predictionvalidation

Identifiers

PMID40599222
PMCPMC12212411

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