Evidence map›Paper›PMID 40599161›Full record

ArticlebioRxiv : the preprint server for biology2025

Bright Cells, and Inefficient Enzymatic Activity in a Renin Hypomorph Mouse.

Silvia Medrano, Lucas Ferreira de Almeida, Fernando Ruiz-Perez, Alejandro Gutierrez-Hernandez, Hiroki Yamaguchi, Daisuke Matsuoka, Manako Yamaguchi, Jason P Smith, Thomas Wagamon, Maria Luisa S Sequeira-Lopez and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Silvia MedranoChild Health Research Center Department of Pediatrics, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0002-8516-0788
Lucas Ferreira de AlmeidaChild Health Research Center Department of Pediatrics, University of Virginia, Charlottesville, VA, USA.
Fernando Ruiz-PerezChild Health Research Center Department of Pediatrics, University of Virginia, Charlottesville, VA, USA.
Alejandro Gutierrez-HernandezChild Health Research Center Department of Pediatrics, University of Virginia, Charlottesville, VA, USA.
Hiroki YamaguchiChild Health Research Center Department of Pediatrics, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0003-2409-7401
Daisuke MatsuokaChild Health Research Center Department of Pediatrics, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0002-2164-0555
Manako YamaguchiChild Health Research Center Department of Pediatrics, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0002-2880-9165
Jason P SmithChild Health Research Center Department of Pediatrics, University of Virginia, Charlottesville, VA, USA.
Thomas WagamonChild Health Research Center Department of Pediatrics, University of Virginia, Charlottesville, VA, USA.
Maria Luisa S Sequeira-LopezChild Health Research Center Department of Pediatrics, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0002-4459-7940
R Ariel GomezChild Health Research Center Department of Pediatrics, University of Virginia, Charlottesville, VA, USA.ORCID 0000-0002-5124-8255

Funding

Single-Cell Epigenomics, Transcriptomics, and Bioinformatics CoreP50DK096373 · NIDDK · UNIVERSITY OF VIRGINIA · PI ROBERTO Ariel GOMEZ · 2012 to 2026
$13.8M
Plasticity of renin cells in the kidney vasculatureR01DK116718 · NIDDK · UNIVERSITY OF VIRGINIA · PI GOMEZ, ROBERTO ARIEL · 2018 to 2022
$2.8M
Renin cell identity and blood pressure homeostasisR01HL148044 · NHLBI · UNIVERSITY OF VIRGINIA · PI SEQUEIRA-LOPEZ, MARIA LUISA SOLEDAD · 2020 to 2023
$2.7M
NHLBI NIH HHS R01 HL148044NIDDK NIH HHS P50 DK096373NIDDK NIH HHS R01 DK116718
6 · The paper itself

Abstract

Juxtaglomerular (JG) cells are crucial regulators of blood pressure and fluid-electrolyte homeostasis. Under normal conditions, renin secretion by JG cells is sufficient to maintain homeostasis. However, under physiological stress such as narrowing of one of the renal arteries, heart failure, dehydration, or chronic administration of renin-angiotensin system (RAS) inhibitors, additional cells along the renal arterioles are transformed to the renin phenotype to meet the demands for renin and regain homeostasis. In cases of prolonged and persistent stimulation of renin cells, concentric arteriolar hypertrophy develops. The study of renin cell identity, plasticity and function often requires the isolation of this rare cell type. Here, we report on the generation of a mouse model to label renin-expressing cells with a bright fluorescent reporter under control of the

Indexed as

arteriolar hypertrophygene targetinglineage tracingrenin cellsrenin enzymatic activity

Identifiers

PMID40599161
PMCPMC12212442

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.