ArticlebioRxiv : the preprint server for biology2025
IFNγ-induced memory in human macrophages is not sustained by epigenetic changes but the durability of the cytokine itself.
Aleksandr Gorin, Noa Harriott, Vyas Koduvayur, Quen J Cheng, Alexander Hoffmann
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
5 authors.
Aleksandr GorinDepartment of Medicine, Division of Infectious Diseases, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-3330-4970 Noa HarriottDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0009-0003-7455-8998 Vyas KoduvayurDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
Quen J ChengDepartment of Medicine, Division of Infectious Diseases, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-0161-1917 Alexander HoffmannDepartment of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA, USA.
Funding
Regulation of Innate Immune Responses by Alloimmunity in Liver Ischemia-Reperfusion InjuryP01AI120944 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ELAINE F REED · 2017 to 2026
$20.0MUCLA-CDU CFARP30AI152501 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SCOTT G KITCHEN · 2022 to 2026
$15.6MSystems Epigenomics of Persistent Bloodstream InfectionU19AI172713 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI Michael R Yeaman · 2023 to 2026
$11.6MCharacterizing functional states of macrophages via their stimulus-responsesR01AI173214 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Alexander Hoffmann · 2023 to 2026
$2.8MAddressing Evolving Infectious ThreatsT32AI177290 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Risa M. Hoffman, Karin Nielsen · 2023 to 2026
$1.3MThe IRF regulatory network in innate immune training of macrophagesR01AI185026 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Alexander Hoffmann · 2025 to 2026
$1.3MNIAID NIH HHS P01 AI120944NIAID NIH HHS P30 AI152501NIAID NIH HHS R01 AI173214NIAID NIH HHS R01 AI185026NIAID NIH HHS T32 AI177290NIAID NIH HHS U19 AI172713
6 · The paper itselfAbstract
Macrophages, as key sentinel cells of the innate immune system, can retain memory of prior stimulus exposure. Interferon gamma (IFNγ) plays a central role in maintaining trained immunity
Indexed as
de novo enhancerinnate immune memoryinterferon gammamacrophage memoryTrained immunity
Identifiers
PMID40599159
PMCPMC12212440
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