Evidence map›Paper›PMID 40599139›Full record

ArticleJournal of medicine and life2025

PD-L1 Expression and Tumor Microenvironment Dynamics in Diffuse Large B-Cell Lymphoma: Immunophenotypic Insights.

Georgian Halcu, Filip Cristian Mureșan, Andrei Niculae, Anca Evsei-Seceleanu, Mihai-Emilian Lapadat, Mihai Adrian Cerbu, Mihail Ceausu

Abstract read
In one paragraph

Article in Journal of medicine and life, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Georgian HalcuDepartment of Pathology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Filip Cristian MureșanDepartment of Pathology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Andrei NiculaeDepartment of Pathology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Anca Evsei-SeceleanuDepartment of Pathology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Mihai-Emilian LapadatDepartment of Pathology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Mihai Adrian CerbuDepartment of Pathology, Bucharest Emergency University Hospital, Bucharest, Romania.
Mihail CeausuDepartment of Pathology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of B-cell non-Hodgkin lymphoma (NHL) and is characterized by significant biological and clinical heterogeneity. The programmed death 1 (PD-1)/ programmed death-ligand 1 (PD-L1) immune checkpoint pathway plays a crucial role in tumor immune evasion; however, its diagnostic and prognostic relevance in DLBCL remains unclear. We retrospectively analyzed 66 cases of DLBCL diagnosed between 2017 and 2024 at a single institution. Immunohistochemistry was performed on formalin-fixed, paraffin-embedded tissues using antibodies against PD-L1, PD-1, CD4, CD8, and CD68. Clinical data and histopathological features were correlated with marker expression. Statistical analyses were conducted using IBM SPSS 25, with a significance level set at

Indexed as

B7-H1 AntigenLymphoma, Large B-Cell, DiffuseTumor MicroenvironmentAdultAgedAged, 80 and overBiomarkers, TumorFemaleGene Expression Regulation, NeoplasticHumansImmunohistochemistryImmunophenotypingMaleMiddle AgedPrognosisRetrospective StudiesB7-H1 AntigenBiomarkers, TumorCD274 protein, humanB-cell lymphomaimmunohistochemistryPD-L1tumor microenvironment

Identifiers

PMID40599139
PMCPMC12207696

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.