Evidence map›Paper›PMID 40599135›Full record

ArticleGut microbes2025

The accessory type III secretion system effectors collectively shape intestinal inflammatory infection outcomes.

Priyanka Biswas, Julia Sanchez-Garrido, Zuzanna Kozik, Vishwas Mishra, David Ruano-Gallego, Rita Berkachy, Sarah Jordan, Joshua L C Wong, Jyoti S Choudhary, Gad Frankel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. ATPIF1 Deficiency Significantly AlleviatesJournal of microbiology and biotechnology · 2026
    Article
  4. Rehydration rescues Il22Nature communications · 2025
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Priyanka BiswasDepartment of Life Sciences, Imperial College London, London, UK.ORCID 0000-0003-1932-2352
Julia Sanchez-GarridoDepartment of Life Sciences, Imperial College London, London, UK.ORCID 0000-0002-5847-4167
Zuzanna KozikFunctional Proteomics Group, Chester Beatty Laboratories, Institute of Cancer Research, London, UK.ORCID 0000-0001-6713-5776
Vishwas MishraDepartment of Life Sciences, Imperial College London, London, UK.ORCID 0000-0002-7069-4613
David Ruano-GallegoDepartment of Life Sciences, Imperial College London, London, UK.ORCID 0000-0002-2163-2088
Rita BerkachyDepartment of Life Sciences, Imperial College London, London, UK.ORCID 0000-0002-2053-5913
Sarah JordanDepartment of Life Sciences, Imperial College London, London, UK.ORCID 0000-0001-5175-7386
Joshua L C WongDepartment of Life Sciences, Imperial College London, London, UK.ORCID 0000-0001-8437-6731
Jyoti S ChoudharyFunctional Proteomics Group, Chester Beatty Laboratories, Institute of Cancer Research, London, UK.ORCID 0000-0003-0881-5477
Gad FrankelDepartment of Life Sciences, Imperial College London, London, UK.ORCID 0000-0002-0046-1363

Funding

Medical Research Council MR/R02671, RYC2021-031342-IWellcome TrustWellcome Trust 107057/Z/15/Z, 224282/Z/21/Z
6 · The paper itself

Abstract

Injection of effectors via a type III secretion system (T3SS) is an infection strategy shared by various Gram-negative bacterial pathogens, many infecting mucosal surfaces. While individual T3SS effectors are well characterized, their network-level organization and the distinction between core and accessory effectors remain incompletely understood. Here, by systematically dissecting the T3SS effector network of the enteric mouse pathogen

Indexed as

Bacterial ProteinsCitrobacter rodentiumEnterobacteriaceae InfectionsType III Secretion SystemsVirulence FactorsAnimalsDisease Models, AnimalEpithelial CellsIntestinal MucosaMiceMice, Inbred C57BLMice, KnockoutProteomicsVirulenceBacterial ProteinsType III Secretion SystemsVirulence Factorsbarrier disruptionCitrobacter rodentiumgut infectionmucosal immune responsesType III secretion system effectors

Identifiers

PMID40599135
PMCPMC12233879

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.